ArticleThe Journal of pediatrics2021
Variation in Neonatal Transfusion Practice.
Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effect of Liberal versus Restrictive Haemoglobin Thresholds on Cerebral Tissue Oxygenation in Preterm Infants: A Systematic Review and Meta-Analysis.Neonatology · 2026Pooled it
- Tissue Oxygenation Changes After Transfusion and Outcomes in Preterm Infants: A Secondary Near-Infrared Spectroscopy Study of the Transfusion of Prematures Randomized Clinical Trial (TOP NIRS).JAMA network open · 2023Trial
- Plasma transfusion in neonatal sepsis.World journal of pediatrics : WJP · 2026Article
- Sustained practice change after implementation of an evidence-based neonatal platelet transfusion protocol.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Pre-transfusion platelet counts and bleeding in very low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- School-age neurodevelopmental outcomes after non-emergency red blood cell transfusions in preterm infants: a propensity score-matched study from the Epipage 2 cohort.European journal of pediatrics · 2026Observational
- Effects of platelet transfusions on neonatal bleeding and inflammation.Pediatric research · 2026Article
- Pre-Transfusion Platelet Counts and Bleeding in Very Low Birth Weight Infants.Research square · 2026Article
- Neonatal Twin Cobedding: A Mixed Method Study of Policy, Practice and Staff Perceptions in Australia.Journal of advanced nursing · 2026Article
- Determination of the half-life of di(2-ethylhexyl) phthalate (DEHP) in a preterm neonate using blood transfusion as the source of intravenous exposure.Current research in toxicology · 2026Article
- Impact of red blood cell transfusion and transfusion strategies on clinical outcomes in extremely low gestational age neonates.Frontiers in pediatrics · 2026Article
- Microtubular Disruption Alters Intestinal Permeability in Murine Neonatal Anemic Intestine.Anemia · 2026Article
- If things were simple, word would have gotten around. Can complexity science help us improve pediatric research?Pediatric research · 2025Review
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study.BMJ paediatrics open · 2025Observational
- Transfusion Practices in 12 Neonatal Networks: Are We Closer to Adopting a Restrictive Transfusion Approach?Neonatology · 2025Article
- Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study.The Lancet regional health. Europe · 2024Article
- Review
- Platelet Transfusion and Death or Neurodevelopmental Impairment in Children Born Extremely Preterm.JAMA network open · 2024Observational
- Blood Donor Sex and Outcomes in Transfused Infants.Clinics in perinatology · 2023Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
objectiveTo estimate the incidence of blood product transfusion, including red blood cells, platelets, and plasma, and characterize pretransfusion hematologic values for infants during their initial hospitalization after birth. STUDY
designRetrospective cohort study using data from 7 geographically diverse US academic and community hospitals that participated in the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) from 2013 to 2016. Pretransfusion hematologic values were evaluated closest to each transfusion and no more than 24 hours beforehand.
resultsData from 60 243 infants were evaluated. The incidence of any transfusion differed by gestational age (P < .0001), with 80% (95% CI 76%-84%) transfused at <27 weeks of gestation (n = 329) and 0.5% (95% CI 0.5%-0.6%) transfused at ≥37 weeks of gestation (n = 53 919). The median pretransfusion hemoglobin was 11.2 g/dL (10th-90th percentile 8.8-14.1) for the entire cohort, ranging from 10.5 g/dL (8.8-12.3) for infants born extremely preterm at <27 weeks of gestation to 13.0 g/dL (10.5-15.5) for infants born at term. The median pretransfusion platelet count (×10
conclusionsThere is wide variability in pretransfusion hemoglobin, platelet count, and international normalized ratio values for neonatal transfusions. Our findings suggest that a large proportion of neonatal transfusions in the US are administered at thresholds greater than supported by the best-available evidence and highlight an opportunity for improved patient blood management.
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