ReviewThe Lancet. Child & adolescent health2021
Strategies to improve neurodevelopmental outcomes in babies at risk of neonatal hypoglycaemia.
Review in The Lancet. Child & adolescent health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Efficacy of Oral Dextrose Gel for Neonatal Hypoglycaemia: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials With 4368 Patients.Endocrinology, diabetes & metabolism · 2026Pooled it
- Intrapartum maternal glycaemic control for the prevention of neonatal hypoglycaemia: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Early Feeding for the Prevention of Neonatal Hypoglycaemia: A Systematic Review and Meta-Analysis.Neonatology · 2024Pooled it
- Dextrose gel prophylaxis for neonatal hypoglycaemia and neurocognitive function at early school age: a randomised dosage trial.Archives of disease in childhood. Fetal and neonatal edition · 2024Trial
- Diazoxide for Severe or Recurrent Neonatal Hypoglycemia: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Trial
- m6A-Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Umbilical cord blood markers predict neonatal hypoglycemia in full-term small and large for gestational age infants.Pediatric research · 2026Article
- The association between dysglycemia and neonatal respiratory distress syndrome severity as well as short-term clinical outcomes at hospital admission.Frontiers in pediatrics · 2026Article
- Neurodevelopmental trajectories in well-controlled gestational diabetes mellitus offspring: No differences were found at the 6- and 12-month assessments.Frontiers in endocrinology · 2025Article
- Glucose Levels in At-risk Newborns (GLEAN): a prospective cohort study on glucose profiles in infants at risk of hypoglycemia.Frontiers in endocrinology · 2025Article
- Early hypoglycemia is not an independent risk factor for 2-year cognitive impairment in small for gestational age preterm infants of less than 32 weeks.European journal of pediatrics · 2024Article
- Neonatal Hypoglycemia and Neurocognitive Function at School Age: A Prospective Cohort Study.The Journal of pediatrics · 2024Article
- Proposed Screening for Congenital Hyperinsulinism in Newborns: Perspective from a Neonatal-Perinatal Medicine Group.Journal of clinical medicine · 2024Article
- Development and clinical application of a stability-indicating chromatography technique for the quantification of diazoxide.Heliyon · 2023Article
- Metabolic acidosis during continuous glucagon therapy for neonatal hypoglycemia.Paediatrics & child health · 2023Article
- Development of a prediction model for neonatal hypoglycemia risk factors: a retrospective study.Frontiers in endocrinology · 2023Article
- Article
- Application of the screening test principles to screening for neonatal hypoglycemia.Frontiers in pediatrics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Neonatal hypoglycaemia is associated with adverse development, particularly visual-motor and executive function impairment, in childhood. As neonatal hypoglycaemia is common and frequently asymptomatic in at-risk babies-ie, those born preterm, small or large for gestational age, or to mothers with diabetes, it is recommended that these babies are screened for hypoglycaemia in the first 1-2 days after birth with frequent blood glucose measurements. Neonatal hypoglycaemia can be prevented and treated with buccal dextrose gel, and it is also common to treat babies with hypoglycaemia with infant formula and intravenous dextrose. However, it is uncertain if screening, prophylaxis, or treatment improves long-term outcomes of babies at risk of neonatal hypoglycaemia. This narrative review assesses the latest evidence for screening, prophylaxis, and treatment of neonates at risk of hypoglycaemia to improve long-term neurodevelopmental outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.