ArticleCerebral cortex (New York, N.Y. : 1991)2021
Association between Quantitative MR Markers of Cortical Evolving Organization and Gene Expression during Human Prenatal Brain Development.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cross-Species Cortical Geometry Reveals Conserved Gradients Across Primates and Human-Specific Expansion.bioRxiv : the preprint server for biology · 2025Article
- Typical development of the human fetal subplate: regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.bioRxiv : the preprint server for biology · 2025Article
- Linking pregnancy- and birth-related risk factors to a multivariate fusion of child cortical structure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Linking Pregnancy- and Birth-Related Risk Factors to a Multivariate Fusion of Child Cortical Structure.bioRxiv : the preprint server for biology · 2025Article
- Molecular signatures of cortical expansion in the human foetal brain.Nature communications · 2024Article
- Identifying individual brain development using multimodality brain network.Communications biology · 2024Article
- Trajectories of brain and behaviour development in the womb, at birth and through infancy.Nature human behaviour · 2024Review
- Automatic cortical surface parcellation in the fetal brain using attention-gated spherical U-net.Frontiers in neuroscience · 2024Article
- The role of cortical structural variance in deep learning-based prediction of fetal brain age.Frontiers in neuroscience · 2024Article
- Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates.Developmental cognitive neuroscience · 2023Review
- Abnormal development of transient fetal zones in mild isolated fetal ventriculomegaly.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Abnormal prenatal brain development in Chiari II malformation.Frontiers in neuroanatomy · 2023Article
- Editorial: The earliest-born cortical neurons as multi-tasking pioneers: expanding roles for subplate neurons in cerebral cortex organization and function, volume II.Frontiers in neuroanatomy · 2023Article
- Brain charts for the human lifespan.Nature · 2022Article
- Brain MRI Radiomics Analysis of School-Aged Children with Tetralogy of Fallot.Computational and mathematical methods in medicine · 2021Article
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
The relationship between structural changes of the cerebral cortex revealed by Magnetic Resonance Imaging (MRI) and gene expression in the human fetal brain has not been explored. In this study, we aimed to test the hypothesis that relative regional thickness (a measure of cortical evolving organization) of fetal cortical compartments (cortical plate [CP] and subplate [SP]) is associated with expression levels of genes with known cortical phenotype. Mean regional SP/CP thickness ratios across age measured on in utero MRI of 25 healthy fetuses (20-33 gestational weeks [GWs]) were correlated with publicly available regional gene expression levels (23-24 GW fetuses). Larger SP/CP thickness ratios (more pronounced cortical evolving organization) was found in perisylvian regions. Furthermore, we found a significant association between SP/CP thickness ratio and expression levels of the FLNA gene (mutated in periventricular heterotopia, congenital heart disease, and vascular malformations). Further work is needed to identify early MRI biomarkers of gene expression that lead to abnormal cortical development.
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