Evidence map›Paper›PMID 33835956›Full record

ReviewPancreas2021

Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review.

Barbara Kenner, Suresh T Chari, David Kelsen, David S Klimstra, Stephen J Pandol, Michael Rosenthal, Anil K Rustgi, James A Taylor, Adam Yala, Noura Abul-Husn and 24 more

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Pancreas, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06638866 (Artificial Intelligence-based Health Information Management System and Key Technology Study of Early Screening and Hierarchical Diagnosis and Treatment of Pancreatic Cancer), which is not on this map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06638866 recruitingnot on this mapstarted 2024, after this paper: background citation

Artificial Intelligence-based Health Information Management System and Key Technology Study of Early Screening and Hierarchical Diagnosis and Treatment of Pancreatic Cancer

Typeobservational_patient_registrySponsorChanghai HospitalRan2024 to 2030Enrolled5,000ConditionsPancreatic Cancer, Pancreatic Ductal Adenocarcinoma, Pancreatic Intraepithelial Neoplasias, Intraductal Papillary Mucinous NeoplasmArmsPDAC, Pancreatic precursor lesions
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.

  1. Pooled it
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  10. Review
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  12. Toward diffusion MRI in the diagnosis and treatment of pancreatic cancer.Medical oncology (Northwood, London, England) · 2025
    Review
  13. Article
  14. Review
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 18 institutions in 4 countries.

Barbara KennerFrom the Kenner Family Research Fund, New York, NY.
Suresh T ChariDepartment of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX.
David KelsenEdward S. Gordon Chair in Medical Oncology.
David S KlimstraDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
Stephen J PandolBasic and Translational Pancreas Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Michael RosenthalDepartment of Radiology, Dana-Farber Cancer Institute, Boston, MA.
Anil K RustgiDivision of Digestive and Liver Diseases, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY.
James A TaylorGoogle Health, Seattle, WA.
Adam Yala
Noura Abul-HusnDivision of Genomic Medicine, Department of Medicine, Icahn School of Medicine, Mount Sinai, New York, NY.
Dana K AndersenDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
David BernsteinStand Up To Cancer, New York, NY.
Søren BrunakNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Marcia Irene CantoDivision of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD.
Yonina C EldarDepartment of Math and Computer Science, Weizmann Institute of Science, Rehovot, Israel.
Elliot K FishmanDepartment of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD.
Julie FleshmanPancreatic Cancer Action Network, Manhattan Beach.
Vay Liang W GoUCLA Center for Excellence in Pancreatic Diseases, University of California, Los Angeles, Los Angeles, CA.
Jane M HoltNational Pancreas Foundation, Bethesda, MD.
Bruce FieldFrom the Kenner Family Research Fund, New York, NY.
Ann GoldbergFrom the Kenner Family Research Fund, New York, NY.
William Hoos1440 Foundation, Chapel Hill, NC.
Christine Iacobuzio-DonahueDavid M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY.
Debiao LiBiomedical Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Graham LidgardExact Sciences, Madison, WI.
Anirban MaitraDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Lynn M MatrisianPancreatic Cancer Action Network, Manhattan Beach.
Sung PobleteStand Up To Cancer, Los Angeles, CA.
Laura RothschildFrom the Kenner Family Research Fund, New York, NY.
Chris SanderSander Lab, Harvard Medical School, Boston, MA.
Lawrence H SchwartzDepartment of Radiology, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY.
Uri ShalitFaculty of Industrial Engineering and Management, Technion-Israel Institute of Technology, Haifa, Israel.
Sudhir SrivastavaDivision of Cancer Prevention, National Cancer Institute, Bethesda, MD.
Brian WolpinGastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, MA.
The Gordon Hospital · GBColumbia University Irving Medical Center · USDana-Farber Cancer Institute · USMemorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USCedars-Sinai Medical Center · USGoogle (United States) · USHarvard University · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins Medicine · USNational Cancer Institute · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Pancreas Foundation · USPancreatic Cancer Action Network · USTechnion – Israel Institute of Technology · ILTexas Health Dallas · USUniversity of California, Los Angeles · USUSC Norris Comprehensive Cancer Center · US

Funding

The paradoxical roles of beta hydroxy butyrate in the liver pro-metastatic nicheP01CA233452 · NCI · CEDARS-SINAI MEDICAL CENTER · PI BHOWMICK, NEIL A., LU, SHELLY CHI-LOO · 2020 to 2024
$9.5M
Circulating Biomarker Consortium for Pancreatic Cancer Early DetectionU01CA210171 · NCI · DANA-FARBER CANCER INST · PI Michael H. Rosenthal, Brian Matthew Wolpin · 2016 to 2026
$8.7M
Project 3: Role of the pancreatic fibroinflammatory microenvironment in obesity-promoted pancreatic cancerP01CA236585 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EIBL, GUIDO ERWIN MICHAEL · 2020 to 2024
$5.6M
NCI NIH HHS P01 CA233452NCI NIH HHS P01 CA236585NCI NIH HHS U01 CA210171
6 · The paper itself

Abstract

abstractDespite considerable research efforts, pancreatic cancer is associated with a dire prognosis and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly nonspecific. The premise of improved survival through early detection is that more individuals will benefit from potentially curative treatment. Artificial intelligence (AI) methodology has emerged as a successful tool for risk stratification and identification in general health care. In response to the maturity of AI, Kenner Family Research Fund conducted the 2020 AI and Early Detection of Pancreatic Cancer Virtual Summit (www.pdac-virtualsummit.org) in conjunction with the American Pancreatic Association, with a focus on the potential of AI to advance early detection efforts in this disease. This comprehensive presummit article was prepared based on information provided by each of the interdisciplinary participants on one of the 5 following topics: Progress, Problems, and Prospects for Early Detection; AI and Machine Learning; AI and Pancreatic Cancer-Current Efforts; Collaborative Opportunities; and Moving Forward-Reflections from Government, Industry, and Advocacy. The outcome from the robust Summit conversations, to be presented in a future white paper, indicate that significant progress must be the result of strategic collaboration among investigators and institutions from multidisciplinary backgrounds, supported by committed funders.

Indexed as

Artificial IntelligenceBiomarkers, TumorCarcinoma, Pancreatic DuctalEarly Detection of CancerGenomicsHumansInterdisciplinary CommunicationPancreatic NeoplasmsPrognosisSurvival AnalysisBiomarkers, Tumor

Identifiers

PMID33835956
PMCPMC8041569
OpenAlexW3147514193

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.