Evidence map›Paper›PMID 33835770›Full record

ArticleBioconjugate chemistry2021

Synthesis and Comparative

Sai Kiran Sharma, Pierre Adumeau, Outi Keinänen, Vikram Sisodiya, Hetal Sarvaiya, Robert Tchelepi, Joshua A Korsen, Jacob Pourat, Kimberly J Edwards, Ashwin Ragupathi and 6 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Bioconjugate chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Imaging with [The Lancet. Oncology · 2024
    Trial
  2. Article
  3. Review
  4. Pretargeted Trop-2 ImmunoPET for Rapid, Selective Detection of Pancreatic Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  5. Review
  6. Review
  7. Site-specific bioconjugation and nuclear imaging.Current opinion in chemical biology · 2024
    Review
  8. First-in-human imaging with [medRxiv : the preprint server for health sciences · 2024
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Sai Kiran SharmaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Pierre AdumeauDepartment of Chemistry, Hunter College, City University of New York, New York, New York 10021, United States.
Outi KeinänenDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Vikram SisodiyaAbbvie Stemcentrx, South San Francisco, California 94080, United States.
Hetal SarvaiyaAbbvie Stemcentrx, South San Francisco, California 94080, United States.
Robert TchelepiAbbvie Stemcentrx, South San Francisco, California 94080, United States.
Joshua A KorsenDepartment of Pharmacology, Weill Cornell Medical College, New York, New York 10021, United States.
Jacob PouratDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Kimberly J EdwardsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Ashwin RagupathiDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Omar HamdyAbbvie Stemcentrx, South San Francisco, California 94080, United States.
Laura R SaundersAbbvie Stemcentrx, South San Francisco, California 94080, United States.
Charles M RudinDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
John T PoirierDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID 0000-0001-7065-4534
Brian M ZeglisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID 0000-0002-9091-744X
Memorial Sloan Kettering Cancer Center · USAbbVie (United States) · USCity University of New York · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Pretargeted Clinical Imaging of CA19.9 in Pancreatic CancerU01CA221046 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ZEGLIS, BRIAN MATTHEW · 2018 to 2022
$3.5M
The Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4M
Immuno-PET imaging of high-grade neuroendocrine lung tumors using 89Zrrovalpituzumab, a DLL3-targeting monoclonal antibodyR01CA213448 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI POIRIER, JOHN THOMAS, RUDIN, CHARLES M. · 2017 to 2021
$3.1M
Novel Transgenic Mouse Models Addressing Outstanding Translational Barriers in Antibody-Based TherapeuticsR01CA244327 · NCI · ROCKEFELLER UNIVERSITY · PI BOURNAZOS, STYLIANOS · 2020 to 2024
$3.0M
Preclinical development of a DLL3-targeted theranostic for small cell lung cancerU01CA213359 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI POIRIER, JOHN THOMAS · 2017 to 2021
$1.7M
Novel Reagents for Rapid and Stable Thiol-Based BioconjugationsR01CA240963 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2019 to 2023
$1.6M
A PET Radiotracer for Diagnostic and Theranostics Imaging in Lyme DiseaseR21EB030275 · NIBIB · HUNTER COLLEGE · PI QIU, WEIGANG, ZEGLIS, BRIAN MATTHEW · 2020 to 2021
$429k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204167NCI NIH HHS R01 CA213448NCI NIH HHS R01 CA240963NCI NIH HHS R01 CA244327NCI NIH HHS R35 CA232130NCI NIH HHS U01 CA213359NCI NIH HHS U01 CA221046NIBIB NIH HHS R21 EB030275
6 · The paper itself

Abstract

Delta-like ligand 3 (DLL3) is a therapeutic target for the treatment of small cell lung cancer, neuroendocrine prostate cancer, and isocitrate dehydrogenase mutant glioma. In the clinic, DLL3-targeted

Indexed as

AnimalsCell Line, TumorHumansImmunoconjugatesIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceNeoplasmsPositron-Emission TomographyXenograft Model Antitumor AssaysZirconiumDLL3 protein, humanImmunoconjugatesIntracellular Signaling Peptides and ProteinsMembrane ProteinsZirconium

Identifiers

PMID33835770
PMCPMC8295218
OpenAlexW3149845922

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.