ArticleJournal of clinical neurology (Seoul, Korea)2021
Clinical Features and Treatment Outcomes of Seronegative Pediatric Autoimmune Encephalitis.
Article in Journal of clinical neurology (Seoul, Korea), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A systematic review of the epidemiology of pediatric autoimmune encephalitis: disease burden and clinical decision-making.Frontiers in neurology · 2024Pooled it
- Myelin Oligodendrocyte Glycoprotein Antibody-Associated Cerebral Cortical Encephalitis: A Comparative Study With Antibody-Negative and Non-MOG Antibody-Positive Cortical Encephalitis in Chinese Adults.CNS neuroscience & therapeutics · 2026Article
- Prognostic Outcomes in Seropositive and Seronegative Autoimmune Encephalitis.Iranian journal of child neurology · 2026Article
- Evaluation of Pediatric Patients Diagnosed with Encephalitis: Single Center Experience.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Seronegative Immune-Mediated Cerebellar Ataxia in Children: Autoimmune Encephalitis Spectrum Disorder or a Distinct Entity?Children (Basel, Switzerland) · 2025Review
- Clinical impact and safety of brain biopsy in unexplained central nervous system disorders: a real-world cohort study.Annals of clinical and translational neurology · 2025Article
- Ten Years ofNeurology(R) neuroimmunology & neuroinflammation · 2025Article
- Study on clinical features and factors related to long-term outcomes of antibody-negative autoimmune encephalitis.Annals of clinical and translational neurology · 2024Article
- Aetiology and Prognosis of Encephalitis in Korean Children: A Retrospective Single-Centre Study, 2005-2020.Yonsei medical journal · 2024Article
- Higher incidence of acute symptomatic seizures in probable antibody-negative pediatric autoimmune encephalitis than in major antibody-positive autoimmune encephalitis.Frontiers in neurology · 2024Article
- Survival Analysis of Immunotherapy Effects on Relapse Rate in Pediatric and Adult Autoimmune Encephalitis.Neurology · 2023Article
- Antibody-Negative Autoimmune Encephalitis: A Single-Center Retrospective Analysis.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Brazilian autoimmune encephalitis network (BrAIN): antibody profile and clinical characteristics from a multicenter study.Frontiers in immunology · 2023Article
- AI-CoV Study: Autoimmune Encephalitis Associated With COVID-19 and Its Vaccines-A Systematic Review.Journal of clinical neurology (Seoul, Korea) · 2022Article
- First Pediatric Case of Autoimmune Encephalitis Associated With COVID-19 in Costa Rica.Cureus · 2022Article
- Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder.Journal of neurodevelopmental disorders · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeNew diagnostic criteria for pediatric autoimmune encephalitis (AIE) have been introduced recently. A substantial proportion of cases of pediatric AIE are diagnosed as seronegative based on these criteria, and so the clinical characteristics of this group remain to be investigated.
methodsThis study included 46 pediatric patients younger than 18 years with suspected AIE. Clinical features, laboratory or radiological findings, and treatment outcomes were compared between seronegative and seropositive patients.
resultsNine (19.6%) of the 46 patients were diagnosed as seropositive AIE. All of the patients with seropositive AIE had anti-N-methyl-D-aspartate receptor antibodies. Commonly identified neuropsychiatric symptoms were altered mental status, cognitive dysfunction, seizure, speech dysfunction, and psychotic disorder in both the seronegative and seropositive groups. Immunotherapy produced favorable treatment outcomes in both the seropositive (
conclusionsPediatric seronegative AIE patients showed clinical presentations similar to those of seropositive AIE patients, with favorable treatment outcomes after immunotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.