Evidence map›Paper›PMID 33835427›Full record

ArticleEuropean geriatric medicine2021

Identifying key prescribing cascades in older people (iKASCADE): a transnational initiative on drug safety through a sex and gender lens-rationale and design.

Shelley A Sternberg, Mirko Petrovic, Graziano Onder, Antonio Cherubini, Denis O'Mahony, Jerry H Gurwitz, Francesco Pegreffi, Robin Mason, Jennifer Akerman, Lisa McCarthy and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in European geriatric medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shelley A SternbergDepartment of Geriatric Medicine, Maccabi Healthcare Services, Modiin, Israel.
Mirko PetrovicSection of Geriatrics, Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.
Graziano OnderDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Aging, IstitutoSuperiore di Sanità, Rome, Italy.
Antonio CherubiniGeriatria, Accettazione geriatrica e Centro di ricerca per l'invecchiamento. IRCCS INRCA, Ancona, Italy.
Denis O'MahonyDepartment of Medicine (Geriatrics), School of Medicine, University College Cork, Cork, Ireland.
Jerry H GurwitzDivision of Geriatric Medicine and Meyers Primary Care Institute, University of Massachusetts Medical School, Worcester, MA, USA.
Francesco PegreffiDepartment for Life Quality Studies, University of Bologna, Bologna, Italy.
Robin MasonWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Jennifer AkermanWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Lisa McCarthyWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Andrea LawsonWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Joyce LiWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Wei WuWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Paula A RochonWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada. paula.rochon@wchospital.ca.ORCID http://orcid.org/0000-0002-5973-4151

Funding

CIHR
6 · The paper itself

Abstract

purposeTo describe the objectives, methods and expected impact of an international consortium (iKASCADE) whose purpose is to improve drug safety for older adults by addressing prescribing cascades through a sex and gender lens.

methodsTo create a comprehensive, internationally relevant inventory of prescribing cascades affecting older adults, the consortium has created a modified Delphi procedure where international experts in prescribing and managing pharmacotherapy for older adults will rank a list of prescribing cascades as to their clinical importance. We will use administrative and clinical data on older adults to evaluate the frequency of prescribing cascades by sex internationally, in the hospital, long-term care and community settings. Finally, we will use semi-structured interviews and realistic, country-specific vignettes, each incorporating a prescribing cascade with identified sex differences, to explore how socially constructed gender roles contribute to the experience, presentation and management of prescribing cascades.

resultsThe consortium will synthesize the quantitative and qualitative results to produce a position paper and products-aimed at knowledge users within and outside of academia-designed to elevate the importance of integrating a gender dimension in the identification and prevention of prescribing cascades.

conclusionFindings will improve our understanding of how adverse drug events are different between older women and men and inform the development and dissemination of tailored knowledge translation products to reduce the frequency and impact of prescribing cascades.

Indexed as

Drug-Related Side Effects and Adverse ReactionsPharmaceutical PreparationsAgedFemaleHumansInappropriate PrescribingLong-Term CareMalePharmaceutical PreparationsOlder adultsPharmacotherapyPrescribing cascadesSex and gender

Identifiers

PMID33835427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.