Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2021
Psychometric assessment of EQ-5D-5L and ReQoL measures in patients with anxiety and depression: construct validity and responsiveness.
Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Effectiveness of a Brief Internet-Based Workplace Training Program to Support Help Seeking for Mental Ill-Health: Cluster Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- iMAgery Focused Therapy for PSychosis (iMAPS-2): An Assessor-blind Feasibility Randomized Controlled Clinical Trial.Schizophrenia bulletin · 2025Trial
- Psychometric evaluation of the German version of the Recovering Quality of Life (ReQoL) measures in patients with affective disorders.The European journal of health economics : HEPAC : health economics in prevention and care · 2023Trial
- Mobile Diary App Versus Paper-Based Diary Cards for Patients With Borderline Personality Disorder: Economic Evaluation.Journal of medical Internet research · 2021Trial
- Comparative performance of the EQ-5D-5L, EQ-HWB, and PROMIS-10 in screening for history of anxiety and depression in the general adult population in 15 countries.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- The Burden of Disease of Treatment-Seeking Patients With a Cluster-C Personality Disorder in the Netherlands; Quality of Life, Functioning, and Societal Costs.Journal of clinical psychology · 2026Article
- Development and Cross-Sectional Validation of the Quality of Life and Function Five-Domain Scale (QFS-5) in Dementia-Free Community-Dwelling Older Adults.International journal of geriatric psychiatry · 2026Article
- Quality of life, sleep quality, and psychological wellbeing of patients with chronic kidney disease in Sabaragamuwa Province, Sri Lanka: a descriptive cross-sectional study.Scientific reports · 2026Article
- Article
- Socioeconomic inequalities in patient-reported outcome measures among total hip and knee arthroplasty patients: a comprehensive analysis of instruments and domains.International journal for equity in health · 2025Article
- Psychometric properties of Japanese version of the Recovering Quality of Life (ReQoL).BMC psychiatry · 2025Article
- Mapping functions for the PHQ-9 and GAD-7 to generate EQ-5D-3L for economic evaluation.The European journal of health economics : HEPAC : health economics in prevention and care · 2025Article
- Validation of PROMIS anxiety item bank computer adaptive test among patients with heart failure.Frontiers in cardiovascular medicine · 2025Article
- Exploring the Characteristics of Gut Microbiota Associated with Depression via the Depression Assessment Scales.Journal of microbiology and biotechnology · 2024Article
- Article
- Health-related quality of life and utility values among patients with anxiety and/or depression in a low-income tertiary care setting: a cross-sectional analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- A Brief Workplace Training Program to Support Help-Seeking for Mental Ill-Health: Protocol for the Helipad Cluster Randomized Controlled Trial.JMIR research protocols · 2024Article
- Factors associated with quality of life in patients with kidney failure managed conservatively and with dialysis: a cross-sectional study.BMC nephrology · 2023Article
- Enabling QALY estimation in mental health trials and care settings: mapping from the PHQ-9 and GAD-7 to the ReQoL-UI or EQ-5D-5L using mixture models.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Effects of anxiety, depression, social support, and physical health status on the health-related quality of life of pregnant women in post-pandemic Korea: a cross-sectional study.Korean journal of women health nursing · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGeneric health measures have been questioned for quantifying mental-health-related outcomes. In patients with anxiety and/or depression, our aim is to assess the psychometric properties of the preference-based EQ-5D-5L (generic health) and ReQoL-UI (recovery-focussed quality of life) for economic evaluation against the PHQ-9 (depression) and GAD-7 (anxiety). EQ-5D-5L anxiety/depression item and ReQoL-10 are also assessed.
methodsA 2:1 (intervention: control) randomised controlled trial collected measures at baseline and 8 weeks post baseline; in the intervention arm, data were also collected 3, 6, 9, and 12-months post baseline. EQ-5D-5L preference-based scores were obtained from the value set for England (VSE) and 'cross-walked' EQ-5D-3L United Kingdom (UK) value set scores. ReQoL-UI preference-based scores were obtained from its UK value set as applied to seven ReQoL-10 items. EQ-5D-5L and ReQoL measures' construct validity and responsiveness were assessed compared against PHQ-9 and GAD-7 scores and group cut-offs.
results361 people were randomised to intervention (241) or control (120). ReQoL-UI/-10 had better construct validity with depression severity than the EQ-5D-5L (VSE/cross-walk scores), which had relatively better construct validity with anxiety severity than the ReQoL-UI/-10. Across all intervention-arm time-points relative to baseline, responsiveness was generally better for EQ-5D-5L (VSE in particular) than ReQoL-UI, but worse than ReQoL-10.
conclusionThere is insufficient evidence to recommend the ReQoL-UI over EQ-5D-5L for economic evaluations to capture anxiety severity. However, there may be rationale for recommending the ReQoL-UI over the EQ-5D-5L to capture depression severity given its better construct validity, albeit poorer responsiveness, and if recovery-focussed quality of life relative to condition-specific symptomology is the construct of interest.
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