Evidence map›Paper›PMID 33835329›Full record

Trial reportGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2021

Oral nutritional supplements versus a regular diet alone for body weight loss after gastrectomy: a phase 3, multicenter, open-label randomized controlled trial.

Yasuhiro Miyazaki, Takeshi Omori, Kazumasa Fujitani, Junya Fujita, Ryohei Kawabata, Hiroshi Imamura, Kazuyuki Okada, Jeong-Ho Moon, Motohiro Hirao, Jin Matsuyama and 8 more

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 7 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05253716 naunknown statusnot on this mapstarted 2022, after this paper: background citation

The Effects of Immunonutritional Supplement After Total Gastrectomy in Patients With Stage III Gastric Cancer on Long-term Disease-free Survival After Total Gastrectomy in Patients With Stage III Gastric Cancer

TypeinterventionalSponsorJinling Hospital, ChinaRan2022 to 2026Enrolled696ConditionsStage III Gastric CancerArmsONS
NCT05823272 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Oral Nutritional Supplement on Nutritional Status and Clinical Outcome in Gastric Cancer Patients After Total Gastrectomy

TypeinterventionalSponsorJinling Hospital, ChinaRan2024 to 2024Enrolled60ConditionsGastric CancerArmsONS
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 7 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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  16. Effect of anamorelin on body weight in patients with gastric cancer-associated cachexia: an observational study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 1 country.

Yasuhiro MiyazakiDepartment of Gastroenterological Surgery, Osaka General Medical Center, 3-1-56, Bandaihigashi Sumiyoshi-ku, Osaka, 558-8558, Japan. ymiyazaki02@gh.opho.jp.ORCID 0000-0002-8123-687X
Takeshi OmoriOsaka International Cancer Institute, Osaka, Japan.
Kazumasa FujitaniDepartment of Gastroenterological Surgery, Osaka General Medical Center, 3-1-56, Bandaihigashi Sumiyoshi-ku, Osaka, 558-8558, Japan.
Junya FujitaSakai City Medical Center, Sakai, Japan.
Ryohei KawabataOsaka Rosai Hospital, Sakai, Japan.
Hiroshi ImamuraToyonaka Municipal Hospital Osaka, Toyonaka, Japan.
Kazuyuki OkadaHyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan.
Jeong-Ho MoonNTT West Osaka Hospital, Osaka, Japan.
Motohiro HiraoNational Hospital Organization Osaka National Hospital, Osaka, Japan.
Jin MatsuyamaYao Municipal Hospital, Yao, Japan.
Takuro SaitoOsaka University Graduate School of Medicine, Osaka, Japan.
Tsuyoshi TakahashiOsaka University Graduate School of Medicine, Osaka, Japan.
Yukinori KurokawaOsaka University Graduate School of Medicine, Osaka, Japan.
Makoto YamasakiOsaka University Graduate School of Medicine, Osaka, Japan.
Shuji TakiguchiNagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Masaki MoriGraduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yuichiro DokiOsaka University Graduate School of Medicine, Osaka, Japan.
Osaka University Clinical Research Group for Gastroenterological Study
The University of Osaka · JPOsaka Prefectural Medical Center · JPHyogo Prefectural Nishinomiya Hospital · JPKyushu University · JPNagoya City University · JPNTT WEST Osaka Hospital · JPOsaka International Cancer Institute · JPOsaka National Hospital · JPOsaka Rosai Hospital · JPSakai Municipal Hospital · JPToyonaka Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBody weight loss (BWL) after gastrectomy is associated with not only a deteriorated quality of life but also a poor prognosis. Oral nutritional supplements (ONS) may be used to minimize BWL, which is observed in the first 3 months after gastrectomy and becomes stable thereafter, although the results of several randomized trials remain controversial.

methodsWe performed a multicenter, open-label randomized controlled trial including 1003 gastric cancer patients undergoing curative gastrectomy. Patients were assigned to the ONS group or the control group. In the former, 400 ml (400 kcal) per day for 12 weeks as enteral nutrition was planned, and the actual intake amount was recorded daily by patients themselves. The primary endpoint was BWL 1 year after gastrectomy.

resultsBWL data were available in 880 patients (ONS 437, control 443). BWL at 3 months was significantly lower in the ONS group than in the control group (7.1 ± 5.6% and 8.5 ± 5.8%, p = 0.0011). However, the difference gradually declined after 6 months and was not significant 1 year after surgery (9.3 ± 8.2% and 9.8 ± 8.7%, p = 0.37). In the ONS group, 50.4% of patients took more than 200 ml/day of ONS (average 301 ml) and showed significantly less BWL (8.2 ± 7.2%) at 1 year than the control (p = 0.0204).

conclusionThe administration of ONS for 12 weeks after gastrectomy did not improve BWL at 1 year. However, the improvement in BWL remained until 1 year after surgery in patients who took more than 200 kcal/day of ONS.

Indexed as

Quality of LifeStomach NeoplasmsDietGastrectomyHumansWeight LossBody weight lossEnteral nutritionGastrectomyGastric cancerOral nutritional supplement

Identifiers

PMID33835329
OpenAlexW3146820012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.