ArticleActa diabetologica2021
Pregnancy outcomes and maternal characteristics in women with pregestational and gestational diabetes: a retrospective study on 206,917 singleton live births.
Article in Acta diabetologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Outcomes of hyperglycaemia in pregnancy in Africa: Systematic review and meta-analysis.PloS one · 2026Pooled it
- A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes.International journal of environmental research and public health · 2022Pooled it
- Trial
- The impact of FTO and ADRB3 gene variants, physical activity and proper diet on weight gain and perinatal outcomes in pregnant women with obesity.Journal of applied genetics · 2026Article
- Temporal Trends and Determinants of Gestational Diabetes Mellitus and Perinatal Outcomes in Tuscany, Italy (2010-2021).Journal of clinical medicine · 2026Article
- Body Weight-Related Parameters in Pregnancies Complicated by Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis with Maternal and Perinatal Outcome Mapping.Journal of clinical medicine · 2026Review
- miR-326 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability.Irish journal of medical science · 2025Article
- Falling Third Trimester Insulin Requirements and Adverse Pregnancy Outcomes in Individuals with Pre-Existing Diabetes: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Comparison of postpartum depression, anxiety, sleep quality and neonatal outcomes in mothers with pregestational and gestational diabetes.BMC pediatrics · 2025Article
- Pregestational Diabetes Mellitus and Adverse Perinatal Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Maternal and Fetal-Neonatal Complications of Romanian Women with Gestational Diabetes: A Retrospective Comparative Study.Medicina (Kaunas, Lithuania) · 2025Observational
- Pregnancy Outcomes and Maternal Characteristics in Women with Pregestational and Gestational Diabetes: A Population-Based Study in Spain, 2016-2022.Journal of clinical medicine · 2024Article
- Increased purchases of prescription medicines in offspring of women with type 1 diabetes: a Finnish register-based cohort study between 1995 and 2018.Annals of medicine · 2024Article
- Pregnancy outcomes in type 2 versus type 1 diabetes: systematic review with meta-analyses.Endocrine connections · 2024Article
- Maternal and foetal complications of pregestational and gestational diabetes: a descriptive, retrospective cohort study.Scientific reports · 2024Article
- Maternal Diabetes Mellitus and Neonatal Outcomes in Bisha: A Retrospective Cohort Study.Medical sciences (Basel, Switzerland) · 2024Article
- A Brazilian cohort of pregnant women with overt diabetes: analyses of risk factors using a machine learning technique.Archives of endocrinology and metabolism · 2023Article
- Association between weight-adjusted-waist index and female infertility: a population-based study.Frontiers in endocrinology · 2023Article
- DNA Methylation NearPediatric diabetes · 2023Article
- Trends of the Prevalence of Pre-gestational Diabetes in 2030 and 2050 in Belgrade Cohort.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo examine risk of adverse pregnancy outcomes, mothers' characteristics and incidence rate over time of pregestational type 1 (T1D), type 2 (T2D) or gestational diabetes (GDM).
methodsThe study included all singleton live births born from women aged 15-45 year, in Tuscany, Italy from 2010 to 2018. Pregnancy outcomes were retrieved by certificates of care at delivery compiled by midwives. Pregestational diabetes and GDM were identified by regional administrative databases. Time course of pregestational diabetes and GDM across last decade was assessed by Poisson analysis. Logistic regression analysis was used to calculate adjusted odds ratios (OR; 95% CI) for maternal characteristics or neonatal outcomes.
resultsAmong 206,917 singleton live births, GDM was diagnosed in 21,613 pregnancies (10.46%) and pregestational diabetes in 979, being T2D more prevalent than T1D (606; 0.29% vs. 373; 0.18%). Pregestational T2D incidence progressively decreased over last decade, T1D remained stable while GDM progressively rose. Pre-pregnancy obesity, preterm deliveries or cesarean sections were common characteristics of pregestational diabetes and GDM. Risk of neonatal distress and neonatal malformations was higher in pregestational T1D. Risk of prior spontaneous abortions was higher in GDM and in pregestational T2D (OR: 4.19; 3.30-5.33), mostly treated with metformin. Risk of neonatal macrosomia was increased only in pregestational diabetes.
conclusionsIn our population, pregestational T2D was more prevalent than T1D. Neonatal complications were mostly associated with pregestational T1D. Increased risk of previous spontaneous abortions was the hallmark of pregestational T2D. GDM, even if sharing adverse outcomes with pregestational T2D, was unrelated to rise in risk of neonatal macrosomia.
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