Evidence map›Paper›PMID 33835223›Full record

ReviewAbdominal radiology (New York)2021

Therapies for hepatocellular carcinoma: overview, clinical indications, and comparative outcome evaluation-part one: curative intention.

Joseph H Yacoub, Christine C Hsu, Thomas M Fishbein, David Mauro, Andrew Moon, Aiwu R He, Mustafa R Bashir, Lauren M B Burke

Abstract readReview
PubMed Publisher
In one paragraph

Review in Abdominal radiology (New York), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Targeting cuproptosis in liver cancer: Molecular mechanisms and therapeutic implications.Apoptosis : an international journal on programmed cell death · 2025
    Review
  5. Review
  6. Article
  7. Identification ofJournal of gastrointestinal oncology · 2024
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Joseph H YacoubDepartment of Radiology, Medstar Georgetown University Hospital, Georgetown University, 3800 Reservoir Rd, NW, Suite CG201, Washington DC, 20007, USA. joeyacoub@gmail.com.ORCID http://orcid.org/0000-0002-7831-1680
Christine C HsuMedstar Georgetown Transplant Institute, Georgetown University, Washington DC, USA.
Thomas M FishbeinMedstar Georgetown Transplant Institute, Georgetown University, Washington DC, USA.
David MauroDepartment of Radiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA.
Andrew MoonDepartment of Radiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA.
Aiwu R HeDepartment of Medicine, Georgetown University, Washington DC, USA.
Mustafa R BashirDepartment of Radiology and Medicine (Gastroenterology), Duke University School of Medicine, Durham, NC, 27710, USA.
Lauren M B BurkeDepartment of Radiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA.
Georgetown University · USUniversity of North Carolina at Chapel Hill · USDuke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) offers unique management challenges as it commonly occurs in the setting of underlying chronic liver disease. The management of HCC is directed primarily by the clinical stage. The most commonly used staging system is the Barcelona-Clinic Liver Cancer system, which considers tumor burden based on imaging, liver function and the patient's performance status. Early-stage HCC can be managed with therapies of curative intent including surgical resection, liver transplantation, and ablative therapies. This manuscript reviews the various treatment options for HCC with a curative intent, such as locablative therapy types, surgical resection, and transplant. Indications, contraindications and outcomes of the various treatment options are reviewed. Multiple concepts relating to liver transplant are discussed including Milan criteria, OPTN policy, MELD exception points, downstaging to transplant and bridging to transplant.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsLiver TransplantationHumansIntentionNeoplasm StagingTreatment OutcomeAblationCurative TherapiesHepatocellular CarcinomaLiver transplantationLocoregional TherapiesStaging

Identifiers

PMID33835223
OpenAlexW3146548882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.