ArticleJournal of the American Medical Informatics Association : JAMIA2021
CancelRx: a health IT tool to reduce medication discrepancies in the outpatient setting.
Article in Journal of the American Medical Informatics Association : JAMIA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Examining usability of RxFill: integrating health IT to support medication adherence.BMC medical informatics and decision making · 2026Article
- Ambulatory Medication Change Workflows' Effect on Communication to Pharmacies.Applied clinical informatics · 2025Article
- Understanding the Information Needs of Pharmacy Staff Using CancelRx: A Qualitative Study of the Use of PrescriptionExploratory research in clinical and social pharmacy · 2024Article
- From MedWreck to MedRec: A Call to Action to Improve Medication Reconciliation.Applied clinical informatics · 2024Article
- A use case of ChatGPT: summary of an expert panel discussion on electronic health records and implementation science.Frontiers in digital health · 2024Article
- CancelRx case study: implications for clinic and community pharmacy work systems.BMC health services research · 2023Article
- Discontinuation of outpatient medications: implications for electronic messaging to pharmacies using CancelRx.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- CancelRx implementation: Observed changes to medication discontinuation workflows over time.Exploratory research in clinical and social pharmacy · 2022Article
- Impact of CancelRx on discontinuation of controlled substance prescriptions: an interrupted time series analysis.BMC medical informatics and decision making · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveMedication list discrepancies between outpatient clinics and pharmacies can lead to medication errors. Within the last decade, a new health information technology (IT), CancelRx, emerged to send a medication cancellation message from the clinic's electronic health record (EHR) to the outpatient pharmacy's software. The objective of this study was to measure the impact of CancelRx on reducing medication discrepancies between the EHR and pharmacy dispensing software. MATERIALS AND
methodsCancelRx was implemented in October 2017 at an academic health system. For 12 months prior, and 12 months after CancelRx implementation, data were collected on discontinued medications in the health system's EHR and whether those prescriptions were successfully discontinued in the pharmacy's dispensing software. An interrupted time series analysis was conducted to model the occurrence of prescriptions successfully discontinued over time.
resultsThere was an immediate (lag = 0), significant (P < 0.001), and sustained (post-implementation slope 0.02) increase in the proportion of successful medication discontinuations after CancelRx implementation (from 34% to 93%). CancelRx had variable impact based on whether the clinic was primary care (71.4% change prepost) or specialty care (53.9% change prepost). CancelRx reduced the time between when a medication was discontinued in the clinic EHR and pharmacy dispensing software.
conclusionCancelRx automated a manual process and illustrated the role for health IT in communicating medication discontinuations between clinics and pharmacies. Overall, CancelRx had a marked benefit on medication list discrepancies and illustrated how health IT can be used across different settings to improve patient care.
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