Evidence map›Paper›PMID 33835026›Full record

ArticleeLife2021

Effects of an urban sanitation intervention on childhood enteric infection and diarrhea in Maputo, Mozambique: A controlled before-and-after trial.

Jackie Knee, Trent Sumner, Zaida Adriano, Claire Anderson, Farran Bush, Drew Capone, Veronica Casmo, David Holcomb, Pete Kolsky, Amy MacDougall and 10 more

Open access · goldAbstract readControlled Clinical Trial
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Interventions to improve sanitation for preventing diarrhoea.The Cochrane database of systematic reviews · 2023
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  10. Strain-level analyses of public sequencing data to characterizeOne health (Amsterdam, Netherlands) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 4 countries.

Jackie KneeLondon School of Hygiene & Tropical Medicine, Faculty of Infectious Tropical Diseases, Disease Control Department, London, United Kingdom.ORCID 0000-0002-0834-8488
Trent SumnerGeorgia Institute of Technology, School of Civil and Environmental Engineering, Atlanta, United States.
Zaida AdrianoWE Consult ltd, Maputo, Mozambique.
Claire AndersonGeorgia Institute of Technology, School of Civil and Environmental Engineering, Atlanta, United States.
Farran BushGeorgia Institute of Technology, School of Chemical and Biomolecular Engineering, Atlanta, United States.
Drew CaponeGeorgia Institute of Technology, School of Civil and Environmental Engineering, Atlanta, United States.ORCID 0000-0002-2138-6382
Veronica CasmoInstituto Nacional de Saúde, Maputo, Mozambique.
David HolcombUniversity of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, United States.ORCID 0000-0003-4055-7164
Pete KolskyUniversity of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, United States.
Amy MacDougallLondon School of Hygiene & Tropical Medicine, Faculty of Epidemiology and Population Health, Department of Medical Statistics, London, United Kingdom.
Evgeniya MolotkovaGeorgia Institute of Technology, School of Biological Sciences, Atlanta, United States.
Judite Monteiro BragaInstituto Nacional de Saúde, Maputo, Mozambique.
Celina RussoGeorgia Institute of Technology, School of Civil and Environmental Engineering, Atlanta, United States.
Wolf Peter SchmidtLondon School of Hygiene & Tropical Medicine, Faculty of Infectious Tropical Diseases, Disease Control Department, London, United Kingdom.
Jill StewartUniversity of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, United States.ORCID 0000-0002-3474-5233
Winnie ZambranaGeorgia Institute of Technology, School of Civil and Environmental Engineering, Atlanta, United States.
Valentina ZuinYale-NUS College, Division of Social Science, Singapore, Singapore.
Rassul NaláInstituto Nacional de Saúde, Maputo, Mozambique.
Oliver CummingLondon School of Hygiene & Tropical Medicine, Faculty of Infectious Tropical Diseases, Disease Control Department, London, United Kingdom.ORCID 0000-0002-5074-8709
Joe BrownGeorgia Institute of Technology, School of Civil and Environmental Engineering, Atlanta, United States.ORCID 0000-0002-5200-4148
Georgia Institute of Technology · USUniversity of North Carolina at Chapel Hill · USInstituto Nacional de Saúde · MZLondon School of Hygiene & Tropical Medicine · GBYale-NUS College · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a controlled before-and-after trial to evaluate the impact of an onsite urban sanitation intervention on the prevalence of enteric infection, soil transmitted helminth re-infection, and diarrhea among children in Maputo, Mozambique. A non-governmental organization replaced existing poor-quality latrines with pour-flush toilets with septic tanks serving household clusters. We enrolled children aged 1-48 months at baseline and measured outcomes before and 12 and 24 months after the intervention, with concurrent measurement among children in a comparable control arm. Despite nearly exclusive use, we found no evidence that intervention affected the prevalence of any measured outcome after 12 or 24 months of exposure. Among children born into study sites after intervention, we observed a reduced prevalence of

Indexed as

Sanitary EngineeringToilet FacilitiesUrban HealthBacterial InfectionsChild, PreschoolDiarrheaDysentery, BacillaryFemaleHelminthiasisHumansInfantMaleMozambiquePrevalenceReinfectionResidence CharacteristicsSoildiarrheaenteric infectionenvironmental healthepidemiologyglobal healthhumanmedicineneglected tropical diseasessanitationsoil-transmitted helminths

Identifiers

PMID33835026
PMCPMC8121544
OpenAlexW3145032972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.