Observational studyJournal of the American Heart Association2021
Novel Approach to Risk Stratification in Left Ventricular Non-Compaction Using A Combined Cardiac Imaging and Plasma Biomarker Approach.
Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Can left ventricular entropy by cardiac magnetic resonance late gadolinium enhancement be a prognostic predictor in patients with left ventricular non-compaction?Diagnostic and interventional radiology (Ankara, Turkey) · 2023Trial
- Left ventricular excessive trabeculation: pathophysiology, diagnostic challenges, and prognostic significance.Heart failure reviews · 2026Review
- Left ventricular non-compaction in heart failure: contemporary perspective on diagnostic challenges and treatment opportunities.Heart failure reviews · 2026Review
- The spongy heart paradox: balancing bleeding and clotting risk in left ventricular noncompaction cardiomyopathy.Heart failure reviews · 2026Review
- Plasma Level of Stromal Cell-Derived Factor-1 Provides Insight Into Statin Response, But Not Into Left Ventricular Dysfunction in New Unstable Angina.Journal of clinical medicine research · 2025Article
- Prognostic Value of Compact Myocardial Thinning in Patients With Left Ventricular Noncompaction.The American journal of cardiology · 2025Article
- Prognostic prediction of left ventricular myocardial noncompaction using machine learning and cardiac magnetic resonance radiomics.Quantitative imaging in medicine and surgery · 2023Article
- Three-dimensional Whole-Heart Cardiac MRI Sequence for Measuring Trabeculation in Left Ventricular Noncompaction.Radiology. Cardiothoracic imaging · 2022Article
- Certainties and Uncertainties of Cardiac Magnetic Resonance Imaging in Athletes.Journal of cardiovascular development and disease · 2022Review
- Multimodality Cardiac Imaging in Cardiomyopathies: From Diagnosis to Prognosis.Journal of clinical medicine · 2022Review
- Machine learning techniques for arrhythmic risk stratification: a review of the literature.International journal of arrhythmia · 2022Article
- Novel Approach to Risk Stratification in Left Ventricular Non-Compaction Using A Combined Cardiac Imaging and Plasma Biomarker Approach.Journal of the American Heart Association · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Background Left ventricular non-compaction remains a poorly described entity, which has led to challenges of overdiagnosis. We aimed to evaluate if the presence of a thin compacted myocardial layer portends poorer outcomes in individuals meeting cardiac magnetic resonance criteria for left ventricular non-compaction . Methods and Results This was an observational, retrospective cohort study involving individuals selected from the Cleveland Clinic Foundation cardiac magnetic resonance database (N=26 531). Between 2000 and 2018, 328 individuals ≥12 years, with left ventricular non-compaction or excessive trabeculations based on the cardiac magnetic resonance Petersen criteria were included. The cohort comprised 42% women, mean age 43 years. We assessed the predictive ability of myocardial thinning for the primary composite end point of major adverse cardiac events (composite of all-cause mortality, heart failure hospitalization, left ventricular assist device implantation/heart transplant, ventricular tachycardia, or ischemic stroke). At mean follow-up of 3.1 years, major adverse cardiac events occurred in 102 (31%) patients. After adjusting for comorbidities, the risk of major adverse cardiac events was nearly doubled in the presence of significant compacted myocardial thinning (hazard ratio [HR], 1.88 [95% CI, 1.18‒3.00];
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.