Evidence map›Paper›PMID 33834546›Full record

ArticleMagnetic resonance in medicine2021

SNR-enhanced diffusion MRI with structure-preserving low-rank denoising in reproducing kernel Hilbert spaces.

Gabriel Ramos-Llordén, Gonzalo Vegas-Sánchez-Ferrero, Congyu Liao, Carl-Fredrik Westin, Kawin Setsompop, Yogesh Rathi

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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  5. Denoising diffusion MRI: Considerations and implications for analysis.Imaging neuroscience (Cambridge, Mass.) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriel Ramos-LlordénDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4020-705X
Gonzalo Vegas-Sánchez-FerreroDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Congyu LiaoAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Carl-Fredrik WestinDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kawin SetsompopAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yogesh RathiDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI PUJOL, SONIA · 2012 to 2022
$20.9M
Next generation in-vivo diffusion imaging at submillimeter resolutionR01MH116173 · NIMH · STANFORD UNIVERSITY · PI Yogesh Rathi, Kawin Setsompop · 2018 to 2026
$6.2M
Statistical Standardization of CT for the Analysis of Parenchymal Injury Progression in SmokersK25HL143278 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VEGAS SANCHEZ-FERRERO, GONZALO · 2019 to 2023
$935k
Robust Detection of Early Small Airway DiseaseR21HL156229 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VEGAS SANCHEZ-FERRERO, GONZALO · 2021 to 2022
$269k
NHLBI NIH HHS K25 HL143278NHLBI NIH HHS R21 HL156229NIBIB NIH HHS P41 EB015902NIMH NIH HHS R01 MH116173
6 · The paper itself

Abstract

purposeTo introduce, develop, and evaluate a novel denoising technique for diffusion MRI that leverages nonlinear redundancy in the data to boost the SNR while preserving signal information.

methodsWe exploit nonlinear redundancy of the dMRI data by means of kernel principal component analysis (KPCA), a nonlinear generalization of PCA to reproducing kernel Hilbert spaces. By mapping the signal to a high-dimensional space, a higher level of redundant information is exploited, thereby enabling better denoising than linear PCA. We implement KPCA with a Gaussian kernel, with parameters automatically selected from knowledge of the noise statistics, and validate it on realistic Monte Carlo simulations as well as with in vivo human brain submillimeter and low-resolution dMRI data. We also demonstrate KPCA denoising on multi-coil dMRI data.

resultsSNR improvements up to 2.7

conclusionNonlinear redundancy of the dMRI signal can be exploited with KPCA, which allows superior noise reduction/SNR improvements than the MPPCA method, without loss of signal information.

Indexed as

AlgorithmsDiffusion Magnetic Resonance ImagingBrainHumansPrincipal Component AnalysisSignal-To-Noise Ratiodenoisingdiffusion MRIkernellow-ranknoisePCASNR

Identifiers

PMID33834546
PMCPMC8497014

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.