ReviewHistology and histopathology2021
Profiles of inflammation factors and inflammatory pathways around the peri-miniscrew implant.
Review in Histology and histopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Treatment of Class II Malocclusion With Orthodontic Microimplant Anchorage.International dental journal · 2024Trial
- The Role of Persistent Inflammation in the Pathogenesis of Infected Nonunion: A Narrative Review.Immunity, inflammation and disease · 2025Review
- Methods of Orthodontic Microimplant Surface Modifications Providing Antibacterial Properties: A Systematic Review.Materials (Basel, Switzerland) · 2025Review
- Effect and mechanism of Sanqi () in treating periodontitis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Clinical efficacy of micro-implant anchorage in orthodontic treatment.American journal of translational research · 2025Article
- Construction of EGCG/chlorhexidine functionalized coating to reinforce the soft tissue seal at transmucosal region of implants.Regenerative biomaterials · 2025Article
- Therapeutic effect of Micro-Implant Anchorage in orthodontics.Pakistan journal of medical sciences · 2024Article
- Role of immune dysregulation in peri-implantitis.Frontiers in immunology · 2024Review
- The downregulation of tight junction proteins and pIgR in the colonic epithelium causes the susceptibility of EpCAMFrontiers in molecular biosciences · 2024Article
- Associations of Wnt5a expression with liver injury in chronic hepatitis B virus infection.BMC infectious diseases · 2023Article
- Analysis of oral microbiome on temporary anchorage devices under different periodontal conditions.Progress in orthodontics · 2023Article
- Oral microbiome contributes to the failure of orthodontic temporary anchorage devices (TADs).BMC oral health · 2023Article
- Comparison of interleukin expression in gingival crevicular fluid between patients with invisible orthodontics treat-ment and fixed orthodontics treatment.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Microbial flora surrounding orthodontic temporary skeletal anchorage devices: A systematic review.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundPeri-miniscrew implant is a temporary assistant armamentarium for the treatment of severe malocclusion and complex tooth movement, the inflammation around it is the main reason for the failure of orthodontic treatment due to the implant loosening and falling out. Inflammation around the peri-miniscrew implant is associated with the release of pro-inflammatory cytokines. These pro-inflammatory cytokines, in turn, recruit immune cells (such as macrophages, dendritic cells, T cells, and B cells), which can produce and release inflammatory biomarkers, regulate the interaction between immune cells, periodontal ligament cells, osteoblasts, and so on. However, there is currently no effective clinical treatment plan to prevent inflammation around implants. PURPOSE: To investigate the potentially essential factors in the inflammatory response around the peri-miniscrew implant and explore the signaling pathways involved.
methodsHere, we review the studies focused on inflammatory biomarkers (Interleukins, tumor necrosis factor-α (TNF-α), receptor activator of NF-κB ligand (RANKL), matrix metalloproteinases (MMPs), and cellular adhesion molecules (CAMs)) in peri-miniscrew implant crevicular fluid (PMICF), as well as inflammatory signaling pathways (Wnt5a, JNK, Erk1/2, NF-κBp65 and TAB/TAK) in periodontal cells from 1998 to 2020.
resultsA literature search revealed TLR-2, TLR-4, LOX-1, and BMPs are involved in regulating ILs (IL-1β, IL-6, IL-8, and IL-17), TNF-α, RANKL, MMP-2, MMP-9 expression via JNK, Erk1/2, Wnt5a, NF-κBp65, OPN, and TAB/TAK signaling pathways. Among them, IL-1β and IL-6 are the critical inflammation factors in the signaling pathways inducing the inflammatory reaction surrounding implants. Besides, CAM-1 was also regulated by MMP-9 and IL-17.
conclusionThere are considerable potential factors involving regulating inflammatory biomarkers on downstream signaling pathways in peri-minisrew implant crevicular fluid. CLINICAL SIGNIFICANCE: This review provides the substantiation of these cell factors and signaling pathways around peri-miniscrew implants, proposes more practical clinical therapeutic ideas and schemes for improving the stability and clinical efficacy of peri-miniscrew implants.
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