ArticleAdvances in experimental medicine and biology2021
Development of Neuroimaging-Based Biomarkers in Major Depression.
Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Association of platelet-to-lymphocyte ratio with depression risk: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Genetic and neural mechanisms shared by schizophrenia and depression.Molecular psychiatry · 2025Article
- Differences in cognitive deficits and brain functional impairments between patients with first-episode and recurrent depression.BMC psychiatry · 2025Article
- Biomarker-Guided Tailored Therapy in Major Depression.Advances in experimental medicine and biology · 2024Review
- Affective neural circuits and inflammatory markers linked to depression and anxiety symptoms in patients with comorbid obesity.Journal of psychiatric research · 2023Article
- The Serum Brain-Derived Neurotrophic Factor Increases in Serotonin Reuptake Inhibitor Responders Patients with First-Episode, Drug-Naïve Major Depression.Biomedicines · 2023Article
- The Effectiveness of Physical Activity Interventions on Depression in Korea: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2022Review
- Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system.Frontiers in psychiatry · 2022Review
- Computational approaches to treatment response prediction in major depression using brain activity and behavioral data: A systematic review.Network neuroscience (Cambridge, Mass.) · 2022Article
- How Inflammation Affects the Brain in Depression: A Review of Functional and Structural MRI Studies.Journal of clinical neurology (Seoul, Korea) · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A leading goal in the field of biological psychiatry for depression is to find a promising diagnostic biomarker and selection of specific psychiatric treatment mode that is most likely to benefit patients with depression. Recent neuroimaging studies have characterized the pathophysiology of major depressive disorder (MDD) with functional and structural alterations in the neural circuitry involved in emotion or reward processing. Particularly, structural and functional magnetic resonance imaging (MRI) studies have reported that the brain structures deeply involved in emotion regulation or reward processing including the amygdala, prefrontal cortex (PFC), anterior cingulate cortex (ACC), ventral striatum, and hippocampus are key regions that provide useful information about diagnosis and treatment outcome prediction in MDD. For example, it has been consistently reported that elevated activity of the ACC is associated with better antidepressant response in patients with MDD. This chapter will discuss a growing body of evidence that suggests that diagnosis or prediction of outcome for specific treatment can be assisted by a neuroimaging-based biomarker in MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.