Evidence map›Paper›PMID 33834328›Full record

ArticleJournal of assisted reproduction and genetics2021

Correlation between SNPs of PIK3CA, ERBB2 3'UTR, and their interactions with environmental factors and the risk of epithelial ovarian cancer.

Haibo Chen, Zhenyuan Zhai, Qinghai Xie, Yuanbin Lai, Guiping Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Haibo ChenThe Department of Gynecology, Longyan People Hospital, Longyan, 364000, Fujian, China.ORCID http://orcid.org/0000-0003-0877-7650
Zhenyuan ZhaiThe Department of Gynecology, Weihai Central Hospital, Weihai, 264400, Shandong, China.
Qinghai XieThe Department of Gynecology, Longyan People Hospital, Longyan, 364000, Fujian, China.
Yuanbin LaiThe Department of Gynecology, Longyan People Hospital, Longyan, 364000, Fujian, China.
Guiping ChenThe Department of Gynecology, Longyan People Hospital, Longyan, 364000, Fujian, China. chenguiping1125@163.com.
Longyan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the correlation between SNPs at phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) rs9838117 site, erb-b2 receptor tyrosine kinase 2 (ERBB2) rs1058808 site, and their interactions with environmental factors and the epithelial ovarian cancer (EOC) risk.

methodsSanger sequencing was used to analyze the genotypes of PIK3CA rs9838117 and ERBB2 rs1058808 site in 587 patients with epithelial ovarian cancer (EOC). Multi-factor dimensionality reduction (MDR) was applied to analyze the interaction between PIK3CA rs9838117 and ERBB2 rs1058808 site and the clinical data.

resultsThe risk of EOC in T allele carriers at PIK3CA rs9838117 was 1.95 times (95%CI: 1.55-2.46, P<0.01) that of G allele carriers. The risk of EOC in G allele carriers at ERBB2 rs1058808 was as 0.64 times (95%CI: 0.54-0.75, P <0.01) as the risk for C allele carriers. In the interaction model between clinical data, PIK3CA rs9838117 site and ERBB2 rs1058808 SNP site, EOC risk in high-risk combination was 3.10 times (95%CI: 1.49-6.46, P <0.01) that of low-risk combination.

conclusionThe SNPs at PIK3CA rs9838117 and ERBB2 rs1058808 loci were associated with the risk of EOC.

Indexed as

3' Untranslated RegionsGene-Environment InteractionPolymorphism, Single NucleotideAdultAgedCarcinoma, Ovarian EpithelialCase-Control StudiesClass I Phosphatidylinositol 3-KinasesErb-b2 Receptor Tyrosine KinasesFemaleGenetic Predisposition to DiseaseHumansMiddle AgedOvarian NeoplasmsPrognosisRisk Factors3' Untranslated RegionsClass I Phosphatidylinositol 3-KinasesERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesPIK3CA protein, humanEpithelial ovarian cancerERBB2PIK3CASingle nucleotide polymorphismSusceptibility

Identifiers

PMID33834328
PMCPMC8581104
OpenAlexW3142242199

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.