Evidence map›Paper›PMID 33834078›Full record

Observational studyJournal of immunology research2021

Relationships of Rheumatoid Factor with Thickness of Retina and Choroid in Subjects without Ocular Symptoms Using Swept-Source Optical Coherence Tomography.

Qingjian Li, Yiwen Qian, Sennan Xu, Minjie Zhang, Xu Liang, Xin Che, Jing Jiang, Zuguo Liu, Yu Zhang, Yan Liu and 1 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Qingjian LiEye Institute of Xiamen University; School of Medicine, Xiamen University, Department of Ophthalmology, Xiang'an Hospital, Xiamen University, Xiamen, Fujian, China.ORCID https://orcid.org/0000-0002-4495-6253
Yiwen QianDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-8375-645X
Sennan XuEye Institute of Xiamen University; School of Medicine, Xiamen University, Department of Ophthalmology, Xiang'an Hospital, Xiamen University, Xiamen, Fujian, China.
Minjie ZhangEye Institute of Xiamen University; School of Medicine, Xiamen University, Department of Ophthalmology, Xiang'an Hospital, Xiamen University, Xiamen, Fujian, China.
Xu LiangEye Institute of Xiamen University; School of Medicine, Xiamen University, Department of Ophthalmology, Xiang'an Hospital, Xiamen University, Xiamen, Fujian, China.
Xin CheDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Jing JiangDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Zuguo LiuEye Institute of Xiamen University; School of Medicine, Xiamen University, Department of Ophthalmology, Xiang'an Hospital, Xiamen University, Xiamen, Fujian, China.
Yu ZhangDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-6604-3298
Yan LiuDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-0139-6137
Zhiliang WangDepartment of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-0944-8584
Fudan University · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeResearches have confirmed that the retinal and choroidal thickness in patients with autoimmune disease-associated uveitis displays significant changes. However, the relationships between rheumatoid factor (RF) and thickness of the retina and choroid in individuals without ocular manifestations remain unclear. The aim of this study is to assess the associations of RF with retinal and choroidal thickness.

methodsThe individuals enrolled in the cross-sectional research received full ocular examinations. The participants were classified as the RF (+) group (RF ≥ 15.0 IU/ml) and the RF (-) group (RF < 15.0 IU/ml) according to the serum RF titers. The thickness of the retina and choroid was measured by swept-source optical coherence tomography (SS-OCT).

resultsThe study covered 65 right eyes of 65 individuals that are RF-positive and 130 right eyes of 130 age- and sex-matched individuals that are RF-negative. The RF (+) group showed decreased choroidal thickness that achieved statistical significance only in the outer inferior and outer temporal sectors, as compared to the RF (-) group. There was no statistically significant difference regarding the retinal thickness between the two groups. Pearson's correlation analysis revealed that the RF was significantly negatively related to the choroidal thickness in all areas. However, there was no significant correlation between the RF and the retinal thickness.

conclusionsSerum RF titers are closely linked with choroidal thickness before the emergence of ocular symptoms. Research into the relationships may improve our understanding of the role of serum RF in the pathogenesis of uveitis.

Indexed as

AdolescentAdultAgedChoroidCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetinaRheumatoid FactorTomography, Optical CoherenceUveitisYoung AdultRheumatoid Factor

Identifiers

PMID33834078
PMCPMC8016561
OpenAlexW3137648913

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.