Evidence map›Paper›PMID 33834063›Full record

ArticleBioMed research international2021

Dental Pulp Stem Cells on Implant Surface: An In Vitro Study.

Luigi Laino, Marcella La Noce, Luca Fiorillo, Gabriele Cervino, Ludovica Nucci, Diana Russo, Alan Scott Herford, Salvatore Crimi, Alberto Bianchi, Antonio Biondi and 3 more

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. New Implant Materials.Materials (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Luigi LainoMultidisciplinary Departments of Medical-Surgical and Dental Specialties, Second University of Naples, Naples 80100, Italy.
Marcella La NoceMultidisciplinary Departments of Medical-Surgical and Dental Specialties, Second University of Naples, Naples 80100, Italy.
Luca FiorilloMultidisciplinary Departments of Medical-Surgical and Dental Specialties, Second University of Naples, Naples 80100, Italy.ORCID https://orcid.org/0000-0003-0335-4165
Gabriele CervinoDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, Messina 98100, Italy.ORCID https://orcid.org/0000-0003-4619-4691
Ludovica NucciMultidisciplinary Departments of Medical-Surgical and Dental Specialties, Second University of Naples, Naples 80100, Italy.
Diana RussoMultidisciplinary Departments of Medical-Surgical and Dental Specialties, Second University of Naples, Naples 80100, Italy.
Alan Scott HerfordDepartment of Maxillofacial Surgery, Loma Linda University, Loma Linda, CA 92354, USA.
Salvatore CrimiDepartment of Surgical and Biomedical Sciences, Catania University, 95124 Catania, Italy.
Alberto BianchiDepartment of Surgical and Biomedical Sciences, Catania University, 95124 Catania, Italy.
Antonio BiondiDepartment of Surgical and Biomedical Sciences, Catania University, 95124 Catania, Italy.
Gregorio LainoMultidisciplinary Departments of Medical-Surgical and Dental Specialties, Second University of Naples, Naples 80100, Italy.
Antonino GermanàDepartment of Veterinary Sciences, University of Messina, Messina, Italy.
Marco CicciùDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, Messina 98100, Italy.ORCID https://orcid.org/0000-0001-7058-4126
University of Campania "Luigi Vanvitelli" · ITUniversity of Messina · ITUniversity of Catania · ITLoma Linda University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the field of biology and medicine, one hears often about stem cells and their potential. The dental implant new surfaces, subjected to specific treatments, perform better and allow for quicker healing times and better clinical performance. The purpose of this study is to evaluate from a biological point of view the interaction and cytotoxicity between stem cells derived from dental pulp (DPSCs) and titanium surfaces. Through the creation of complex cells/implant, this study is aimed at analyzing the cytotoxicity of dental implant surfaces (Myth (Maipek Manufacturer Industrial Care, Naples, Italy)) and the adhesion capacity of cells on them and at considering the essential factors for implant healing such as osteoinduction and vasculogenesis. These parameters are pointed out through histology (3D cell culture), immunofluorescence, proliferation assays, scanning electron microscopy, and PCR investigations. The results of the dental implant surface and its interaction with the DPSCs are encouraging, obtaining results increasing the mineralization of the tissues. The knowledge of this type of interaction, highlighting its chemical and biological features, is certainly also an excellent starting point for the development of even more performing surfaces for having better healing in the oral surgical procedures related to dental implant positioning.

Indexed as

Dental ImplantsBone MatrixCell AdhesionCell DeathCell ProliferationCulture Media, ConditionedDental PulpHumansNeovascularization, PhysiologicOsseointegrationOsteocalcinStem CellsSurface PropertiesVascular Endothelial Growth Factor ACulture Media, ConditionedDental ImplantsOsteocalcinVascular Endothelial Growth Factor A

Identifiers

PMID33834063
PMCPMC8012148
OpenAlexW3136256164

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.