ReviewFrontiers in cardiovascular medicine2021
Left Bundle Branch Pacing: Current Knowledge and Future Prospects.
Review in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Outcomes of Left Bundle Branch Area Pacing in Heart Failure Patients: A Systematic Review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Pooled it
- Conduction system pacing is superior to biventricular pacing in patients with heart failure: Insights from the pooled clinical studies.Frontiers in physiology · 2023Pooled it
- Transthoracic Echocardiography-Assisted, Low-Fluoroscopy Left Bundle Branch Area Pacing: A Comparison of Implantation Approaches and Lead Types.Diagnostics (Basel, Switzerland) · 2026Article
- Electromechanical window as an integrative marker of remodeling and arrhythmic risk in biventricular vs. left bundle branch area pacing.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026Article
- Computational Modelling of Selective Capture Mechanisms in Conduction System Pacing.Annals of biomedical engineering · 2026Article
- The importance of contrast fluoroscopy during left bundle branch area pacing: A case report of septal venous channel perforation during implantation.HeartRhythm case reports · 2026Article
- Left ventricular functional outcomes in His vs. left bundle branch area pacing: Is lead distance important in LBBAP implantation?BMC cardiovascular disorders · 2026Observational
- CUSUM Analysis as a Predictive Tool for the Learning Curve in Left Bundle Branch Area Pacing.Journal of clinical medicine · 2026Article
- Left Bundle Branch Area Pacing Preserves Mechanical Strain and Synchrony Compared to Right Ventricular Apical Pacing in an Acute Paired Preclinical Model.bioRxiv : the preprint server for biology · 2025Article
- Tissue attached to retrieved left bundle pacing leads: histopathological evaluation of tissue composition in relation to difficult lead advancement.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Left bundle branch area pacing prevails over His bundle pacing for heart failure patients undergoing atrioventricular node ablation in permanent atrial fibrillation: a network meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Review
- Article
- Impact of a Practice-wide Switch from Traditional Right Ventricular Pacing to Left Bundle Branch Area Pacing.The Journal of innovations in cardiac rhythm management · 2025Article
- Learning Curve for Left Bundle Branch Area Pacing Lead Implantation.The Journal of innovations in cardiac rhythm management · 2025Article
- The Functional and Imaging Implications of Left Bundle Branch Pacing in Ischemic Cardiomyopathy.Biomolecules · 2025Review
- Left bundle branch pacing in a 4-year-old patient with complete heart block after correction of transposition of the great arteries via a dual chamber pacing system: a case report.Frontiers in cardiovascular medicine · 2025Article
- Relationship between endocardial R-wave amplitude at the apical lead location and regional right ventricular strain analysis.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Current Advance, Challenges and Future Perspectives of Conduction System Pacing.Reviews in cardiovascular medicine · 2024Review
- Article
- Concepts of Cardiac Dyssynchrony and Dynamic Approach.Diagnostics (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac pacing is an effective therapy for treating patients with bradycardia due to sinus node dysfunction or atrioventricular block. However, traditional right ventricular apical pacing (RVAP) causes electric and mechanical dyssynchrony, which is associated with increased risk for atrial arrhythmias and heart failure. Therefore, there is a need to develop a physiological pacing approach that activates the normal cardiac conduction and provides synchronized contraction of ventricles. Although His bundle pacing (HBP) has been widely used as a physiological pacing modality, it is limited by challenging implantation technique, unsatisfactory success rate in patients with wide QRS wave, high pacing capture threshold, and early battery depletion. Recently, the left bundle branch pacing (LBBP), defined as the capture of left bundle branch (LBB) via transventricular septal approach, has emerged as a newly physiological pacing modality. Results from early clinical studies have demonstrated LBBP's feasibility and safety, with rare complications and high success rate. Overall, this approach has been found to provide physiological pacing that guarantees electrical synchrony of the left ventricle with low pacing threshold. This was previously specifically characterized by narrow paced QRS duration, large R waves, fast synchronized left ventricular activation, and correction of left bundle branch block. Therefore, LBBP may be a potential alternative pacing modality for both RVAP and cardiac resynchronization therapy with HBP or biventricular pacing (BVP). However, the technique's widespread adaptation needs further validation to ascertain its safety and efficacy in randomized clinical trials. In this review, we discuss the current knowledge of LBBP.
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