Evidence map›Paper›PMID 33833854›Full record

ArticleOxidative medicine and cellular longevity2021

Acteoside Counteracts Interleukin-1

HyangI Lim, Do Kyung Kim, Tae-Hyeon Kim, Kyeong-Rok Kang, Jeong-Yeon Seo, Seung Sik Cho, Younghee Yun, Ye-Yong Choi, Jungtae Leem, Hyoun-Woo Kim and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Research progress and prospect of MAPK signaling pathway in knee osteoarthritis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
    Review
  6. Review
  7. Article
  8. The pharmacokinetic property and pharmacological activity of acteoside: A review.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

HyangI LimInstitute of Dental Science, Chosun University, Gwangju 61452, Republic of Korea.ORCID https://orcid.org/0000-0002-2728-4205
Do Kyung KimInstitute of Dental Science, Chosun University, Gwangju 61452, Republic of Korea.ORCID https://orcid.org/0000-0001-6254-946X
Tae-Hyeon KimInstitute of Dental Science, Chosun University, Gwangju 61452, Republic of Korea.ORCID https://orcid.org/0000-0002-2544-8608
Kyeong-Rok KangInstitute of Dental Science, Chosun University, Gwangju 61452, Republic of Korea.ORCID https://orcid.org/0000-0003-1369-3865
Jeong-Yeon SeoInstitute of Dental Science, Chosun University, Gwangju 61452, Republic of Korea.ORCID https://orcid.org/0000-0002-9290-364X
Seung Sik ChoDepartment of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Jeonnam 58554, Republic of Korea.ORCID https://orcid.org/0000-0003-1497-0529
Younghee YunChung-Yeon Medical Institute, Gwangju 61949, Republic of Korea.ORCID https://orcid.org/0000-0001-8489-8476
Ye-Yong ChoiChung-Yeon Medical Institute, Gwangju 61949, Republic of Korea.ORCID https://orcid.org/0000-0001-8621-5325
Jungtae LeemChung-Yeon Medical Institute, Gwangju 61949, Republic of Korea.ORCID https://orcid.org/0000-0003-3300-5556
Hyoun-Woo KimJeollanamdo Forest Resources Institute, Naju, Jeollanamdo, 58213, Republic of Korea.ORCID https://orcid.org/0000-0002-8592-6405
Geon-Ung JoJeollanamdo Forest Resources Institute, Naju, Jeollanamdo, 58213, Republic of Korea.ORCID https://orcid.org/0000-0002-9835-6632
Chan-Jin OhJeollanamdo Forest Resources Institute, Naju, Jeollanamdo, 58213, Republic of Korea.ORCID https://orcid.org/0000-0001-7582-6761
Deuk-Sil OhJeollanamdo Forest Resources Institute, Naju, Jeollanamdo, 58213, Republic of Korea.ORCID https://orcid.org/0000-0002-6724-3459
Hong-Sung ChunDepartments of Biomedical Science, Chosun University, Gwangju 61452, Republic of Korea.ORCID https://orcid.org/0000-0003-4174-0139
Jae-Sung KimInstitute of Dental Science, Chosun University, Gwangju 61452, Republic of Korea.ORCID https://orcid.org/0000-0002-3584-6351
Chosun University · KRHuman Resources Development Institute · USChungwoon University · KRMokpo National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is the most common degenerative joint disease with chronic joint pain caused by progressive degeneration of articular cartilage at synovial joints. Acteoside, a caffeoylphenylethanoid glycoside, has various biological activities such as antimicrobial, anti-inflammatory, anticancer, antioxidative, cytoprotective, and neuroprotective effect. Further, oral administration of acteoside at high dosage does not cause genotoxicity. Therefore, the aim of present study is to verify the anticatabolic effects of acteoside against osteoarthritis and its anticatabolic signaling pathway. Acteoside did not decrease the viabilities of mouse fibroblast L929 cells used as normal cells and primary rat chondrocytes. Acteoside counteracted the IL-1

Indexed as

Signal TransductionAnimalsAnti-Inflammatory AgentsCartilage, ArticularCell LineCells, CulturedChondrocytesCyclooxygenase 2DinoprostoneGlucosidesImmunosuppressive AgentsInterleukin-1betaMatrix MetalloproteinasesNF-kappa BNitric OxideNitric Oxide Synthase Type IIacteosideAnti-Inflammatory AgentsCyclooxygenase 2DinoprostoneGlucosidesImmunosuppressive AgentsInterleukin-1betaMatrix MetalloproteinasesNF-kappa BNitric OxideNitric Oxide Synthase Type IIPhenolsPolyphenols

Identifiers

PMID33833854
PMCPMC8016581
OpenAlexW3112826971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.