ArticleFrontiers in physiology2021
Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Mapping and ablation of ventricular fibrillation substrate.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
- Functional conduction system mapping in sheep reveals Purkinje spikes in the free wall of the right ventricular outflow tract.Frontiers in physiology · 2025Article
- To reconnect or not reconnect distal Purkinje fibers, that is the question when modeling the Purkinje fiber network.Frontiers in physiology · 2025Article
- Conduction delays across the specialized conduction system of the heart: Revisiting atrioventricular node (AVN) and Purkinje-ventricular junction (PVJ) delays.Frontiers in cardiovascular medicine · 2023Article
- Deep neural networks reveal novel sex-specific electrocardiographic features relevant for mortality risk.European heart journal. Digital health · 2022Article
- Long-term freedom from ventricular fibrillation despite persistent Purkinje ectopy after catheter ablation.HeartRhythm case reports · 2022Article
- Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation.European heart journal · 2022Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.
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