ReviewFrontiers in neuroscience2021
The Contribution of Gut Microbiota-Brain Axis in the Development of Brain Disorders.
Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prenatal Maternal Stress and Infant Gut Microbiome in Human and Animal Studies: A Comprehensive Systematic Review.Developmental psychobiology · 2026Pooled it
- Effects of Probiotic Supplementation on Core Symptoms of Autism Spectrum Disorder in Children.Nutrients · 2026Pooled it
- Pooled it
- From gut to brain: unveiling probiotic effects through a neuroimaging perspective-A systematic review of randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- Gut Microbiome Changes in Preclinical Alzheimer's Disease.Nutrients · 2026Review
- Psychobiotics and Mental Health in 2024 Among Romanian Consumers: A Cross-Sectional Survey.Health science reports · 2026Article
- The Regulatory Role of FABP4 in Microbiome-Brain-Gut Communication Under High-Fat-Diet Conditions.International journal of molecular sciences · 2026Review
- Gerobiotics and neuroprotection: effects on the gut-brain axis in age-related neurodegenerative diseases.Frontiers in aging neuroscience · 2026Review
- Gerobiotics: Exploring the Potential and Limitations of Repurposing Probiotics in Addressing Aging Hallmarks and Chronic Diseases.Probiotics and antimicrobial proteins · 2026Review
- Assessment of the beneficial effects ofFrontiers in neuroscience · 2026Article
- Quercetin hybrid-hydrogel microparticles modulate gut microbiota and improve memory in an antibiotic-induced dysbiosis rat model.Scientific reports · 2025Article
- Gut Microbiotas, Plasma Metabolites, and Autism Spectrum Disorder: A Bidirectional Mendelian Randomization Analysis.Pathogens (Basel, Switzerland) · 2025Article
- Review
- Non-starch polysaccharides and health: gut-target organ axis influencing obesity.Food science and biotechnology · 2025Review
- Role of Vitamin D Status and Alterations in Gut Microbiota Metabolism in Fibromyalgia-Associated Chronic Inflammatory Pain.Biomedicines · 2025Article
- Assessing the causal association between celiac disease and autism spectrum disorder: A two-sample Mendelian randomization approach.Autism research : official journal of the International Society for Autism Research · 2025Article
- A comprehensive overview of the effects of probiotics, prebiotics and synbiotics on the gut-brain axis.Frontiers in microbiology · 2025Review
- Integrated analysis of metabolome and microbiome in a mouse model of sodium valproate-induced autism.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- A closer look at the role of nutrition in children and adults with ADHD and neurodivergence.Frontiers in nutrition · 2025Article
- The effects of a semen cuscutae flavonoids-based antidepressant treatment on microbiome and metabolome in mice.Frontiers in microbiology · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different bacterial families colonize most mucosal tissues in the human organism such as the skin, mouth, vagina, respiratory, and gastrointestinal districts. In particular, the mammalian intestine hosts a microbial community of between 1,000 and 1,500 bacterial species, collectively called "microbiota." Co-metabolism between the microbiota and the host system is generated and the symbiotic relationship is mutually beneficial. The balance that is achieved between the microbiota and the host organism is fundamental to the organization of the immune system. Scientific studies have highlighted a direct correlation between the intestinal microbiota and the brain, establishing the existence of the gut microbiota-brain axis. Based on this theory, the microbiota acts on the development, physiology, and cognitive functions of the brain, although the mechanisms involved have not yet been fully interpreted. Similarly, a close relationship between alteration of the intestinal microbiota and the onset of several neurological pathologies has been highlighted. This review aims to point out current knowledge as can be found in literature regarding the connection between intestinal dysbiosis and the onset of particular neurological pathologies such as anxiety and depression, autism spectrum disorder, and multiple sclerosis. These disorders have always been considered to be a consequence of neuronal alteration, but in this review, we hypothesize that these alterations may be non-neuronal in origin, and consider the idea that the composition of the microbiota could be directly involved. In this direction, the following two key points will be highlighted: (1) the direct cross-talk that comes about between neurons and gut microbiota, and (2) the degree of impact of the microbiota on the brain. Could we consider the microbiota a valuable target for reducing or modulating the incidence of certain neurological diseases?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.