Evidence map›Paper›PMID 33833637›Full record

ArticleJournal of applied crystallography2021

The XBI BioLab for life science experiments at the European XFEL.

Huijong Han, Ekaterina Round, Robin Schubert, Yasmin Gül, Jana Makroczyová, Domingo Meza, Philipp Heuser, Martin Aepfelbacher, Imrich Barák, Christian Betzel and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of applied crystallography, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 9 countries.

Huijong HanEuropean XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID https://orcid.org/0000-0002-1197-3014
Ekaterina RoundEuropean Molecular Biology Laboratory, Notkestrasse 85, 22607 Hamburg, Germany.
Robin SchubertEuropean XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID https://orcid.org/0000-0002-6213-2872
Yasmin GülEuropean Molecular Biology Laboratory, Notkestrasse 85, 22607 Hamburg, Germany.
Jana MakroczyováEuropean XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID https://orcid.org/0000-0001-6769-5597
Domingo MezaBiodesign Center for Applied Structural Discovery and School of Molecular Sciences, Arizona State University, Tempe, AZ, USA.
Philipp HeuserEuropean Molecular Biology Laboratory, Notkestrasse 85, 22607 Hamburg, Germany.
Martin AepfelbacherInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Imrich BarákInstitute of Molecular Biology, Slovak Academy of Sciences, Dúbravská cesta 21, 845 51 Bratislava, Slovak Republic.ORCID https://orcid.org/0000-0002-3690-404X
Christian BetzelInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, University of Hamburg, c/o DESY, Building 22a, Notkestrasse 85, 22603 Hamburg, Germany.
Petra FrommeBiodesign Center for Applied Structural Discovery and School of Molecular Sciences, Arizona State University, Tempe, AZ, USA.
Inari KursulaBiocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland.ORCID https://orcid.org/0000-0001-5236-7056
Poul NissenDANDRITE, Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Department of Molecular Biology and Genetics, Gustav Wieds Vej 10C, DK - 8000 Aarhus C, Denmark.ORCID https://orcid.org/0000-0003-0948-6628
Elena TereschenkoInstitute of Crystallography, Russian Academy of Sciences, 59 Leninsky prospekt, Moscow, 117333, Russian Federation.ORCID https://orcid.org/0000-0001-5035-6978
Joachim SchulzEuropean XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID https://orcid.org/0000-0002-9310-8832
Charlotte UetrechtEuropean XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany.ORCID https://orcid.org/0000-0002-1991-7922
Jozef UlicnýDepartment of Biophysics, Institute of Physics, Faculty of Science, P. J. Šafárik University, Jesenná 5, 04154 Košice, Slovak Republic.ORCID https://orcid.org/0000-0003-2853-8227
Matthias WilmannsEuropean Molecular Biology Laboratory, Notkestrasse 85, 22607 Hamburg, Germany.
Janos HajduThe European Extreme Light Infrastructure, Institute of Physics, Academy of Sciences of the Czech Republic, Za Radnici 835, 25241 Dolní Břežany, Czech Republic.ORCID https://orcid.org/0000-0002-3747-2760
Victor S LamzinEuropean Molecular Biology Laboratory, Notkestrasse 85, 22607 Hamburg, Germany.
Kristina LorenzenEuropean XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany.
European Molecular Biology Laboratory · DEEuropean X-Ray Free-Electron Laser · DEUniversität Hamburg · DEArizona State University · USSlovak Academy of Sciences · SKAarhus University · DKFZU ‒ Institute of Physics of the Academy of Sciences of the Czech Republic · CZLeibniz Institute of Virology (LIV) · DERussian Academy of Sciences · RUUniversity of Bergen · NOUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The science of X-ray free-electron lasers (XFELs) critically depends on the performance of the X-ray laser and on the quality of the samples placed into the X-ray beam. The stability of biological samples is limited and key biomolecular transformations occur on short timescales. Experiments in biology require a support laboratory in the immediate vicinity of the beamlines. The XBI BioLab of the European XFEL (XBI denotes XFEL Biology Infrastructure) is an integrated user facility connected to the beamlines for supporting a wide range of biological experiments. The laboratory was financed and built by a collaboration between the European XFEL and the XBI User Consortium, whose members come from Finland, Germany, the Slovak Republic, Sweden and the USA, with observers from Denmark and the Russian Federation. Arranged around a central wet laboratory, the XBI BioLab provides facilities for sample preparation and scoring, laboratories for growing prokaryotic and eukaryotic cells, a Bio Safety Level 2 laboratory, sample purification and characterization facilities, a crystallization laboratory, an anaerobic laboratory, an aerosol laboratory, a vacuum laboratory for injector tests, and laboratories for optical microscopy, atomic force microscopy and electron microscopy. Here, an overview of the XBI facility is given and some of the results of the first user experiments are highlighted.

Indexed as

coherent diffractive imaging (CDI)European XFEL (EuXFEL)free-electron lasers (XFELs)sample preparation and characterizationserial femtosecond crystallography (SFX)single-particle imaging (SPI)structural biologytime-resolved experimentsXBI Laboratory

Identifiers

PMID33833637
PMCPMC7941304
OpenAlexW3110396249

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.