ReviewThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2021
Ketorolac in Postoperative Neonates and Infants: A Systematic Review.
Review in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Post-Operative Ketorolac in Children After Crohn's Ileocecectomy.Pediatric surgery international · 2026Article
- Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants.The Cochrane database of systematic reviews · 2023Review
- Pain Evaluation and Treatment in Children: A Practical Approach.Children (Basel, Switzerland) · 2023Review
- Non-opioid analgesics for procedural pain in neonates.The Cochrane database of systematic reviews · 2023Review
- Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial.Anesthesiology and pain medicine · 2023Article
- The Development of an Enhanced Recovery Protocol for Kasai Portoenterostomy.Children (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the pharmacokinetics and pharmacodynamics, dosing, efficacy, and safety of ketorolac in postoperative patients younger than 6 months of age.
methodsPubMed (1988-July 2020), Medline (1946-July 2020), and EBSCO Discovery Service (1988-July 2020) were searched to identify relevant published articles using the following search terms: ketorolac, neonate, infant. English-language articles evaluating the use of ketorolac in infants younger than 6 months of age were included.
resultsEight reports that included 239 infants receiving ketorolac were included. Of the included patients, 237 were younger than 6 months of age. Ketorolac exhibits rapid elimination of the analgesia-producing S (-) isomer, elimination half-life of 0.83 hours. Most patients received 0.5 mg/kg/dose every 6 hours for 48 to 72 hours. Analgesia was demonstrated by reduced use of open-label morphine and significant lowering of Neonatal/Infant Pain Scale scores. Adverse effects were minimal when ketorolac was used in term neonates and infants without baseline renal dysfunction.
conclusionsRandomized placebo-controlled trials of ketorolac use in this population are lacking; however, most published reports noted efficacy and safety with ketorolac in properly selected infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.