Evidence map›Paper›PMID 33833618›Full record

ArticleMediators of inflammation2021

Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients.

Cai-Xia Li, Jian Chen, Shu-Kai Lv, Jin-Hui Li, Lei-Lei Li, Xiao Hu

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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  11. Extracellular Vesicles: The Invisible Heroes and Villains of COVID-19 Central Neuropathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cai-Xia LiThe Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, Zhejiang, China.ORCID https://orcid.org/0000-0002-2128-8862
Jian ChenThe Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, Zhejiang, China.
Shu-Kai LvThe Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, Zhejiang, China.
Jin-Hui LiThe Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, Zhejiang, China.
Lei-Lei LiThe Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, Zhejiang, China.
Xiao HuThe Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, Zhejiang, China.ORCID https://orcid.org/0000-0001-7323-480X
Zhejiang University · CNFirst Affiliated Hospital Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially identified in China and currently worldwide dispersed, resulting in the coronavirus disease 2019 (COVID-19) pandemic. Notably, COVID-19 is characterized by systemic inflammation. However, the potential mechanisms of the "cytokine storm" of COVID-19 are still limited. In this study, fourteen peripheral blood samples from COVID-19 patients (

Indexed as

SARS-CoV-2AdultAgedCase-Control StudiesCOVID-19Cytokine Release SyndromeCytokinesExome SequencingFemaleGene ExpressionHumansInflammation MediatorsMaleMicroRNAsMiddle AgedPandemicsCytokinesInflammation MediatorsMicroRNAsRNARNA, Long NoncodingRNA, Messenger

Identifiers

PMID33833618
PMCPMC8018221
OpenAlexW3150764908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.