Observational studyNature immunology2021
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4
Open access · greenAbstract readObservational Study
In one paragraph
Observational study in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 64 citations in OpenAlex.
- A Gene-Program Architecture of Mouse T cells.bioRxiv : the preprint server for biology · 2026Article
- Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency-mediated disease.JCI insight · 2026Article
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Article
- CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Multimerizing transcription factors FOXP3 and AIRE as chromatin architectural regulators.Nature immunology · 2026Review
- c-FLIP as a master regulator of immune homeostasis and disease mechanisms.Cell death & disease · 2026Review
- Development of a pediatric immune cell atlas and characterization of CD4+ T cells in food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Review
- Review
- FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites.Cell reports · 2025Article
- Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets.Nature communications · 2025Article
- Inborn errors of regulatory T-cell differentiation and function.The Journal of allergy and clinical immunology · 2025Review
- Beyond the Classical Triad: Atypical Presentations and Regulatory T Cell Phenotyping in a Cohort of IPEX Patients.Journal of clinical immunology · 2025Article
- FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites.bioRxiv : the preprint server for biology · 2025Article
- Regulatory T Cell Sub-Populations in Patients with Distinct Autoimmune/Inflammatory Diseases With or Without Inborn Errors of Immunity.Diagnostics (Basel, Switzerland) · 2025Article
- Case report: anti-IL-6 autoantibodies in a patient with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.Frontiers in immunology · 2025Article
- Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease.Frontiers in immunology · 2025Review
- The 'TNature reviews. Rheumatology · 2025Review
- Regulatory T cells in immune checkpoint blockade antitumor therapy.Molecular cancer · 2024Review
- Diverse Clinical and Immunological Profiles in Patients with IPEX Syndrome: a Multicenter Analysis from Turkey.Journal of clinical immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 8 institutions in 3 countries.
David ZemmourDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Louis-Marie CharbonnierDivision of Immunology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4594-7893
Juliette LeonDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Emmanuelle SixINSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.ORCID http://orcid.org/0000-0001-7806-0968
Sevgi KelesDivision of Pediatric Allergy and Immunology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.ORCID http://orcid.org/0000-0001-7344-8947
Marianne DelvilleINSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.ORCID http://orcid.org/0000-0002-9585-2307
Mehdi BenamarDivision of Immunology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Safa BarisDivision of Pediatric Allergy and Immunology, Marmara University School of Medicine, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-4730-9422
Julien ZuberINSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.
Karin ChenDivision of Allergy and Immunology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Benedicte NevenINSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.
Maria I Garcia-LloretDivision of Allergy, Immunology, and Rheumatology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Frank M RuemmeleINSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.
Carlo BrugnaraDivision of Immunology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Nadine Cerf-BensussanINSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.
Frederic Rieux-LaucatINSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.
Marina CavazzanaBiotherapy Department and Clinical Investigation Center, Assistance Publique Hopitaux Paris, Inserm, Paris, France.
Isabelle AndréINSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.
Talal A ChatilaDivision of Immunology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7439-2762
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA, USA. cbdm@hms.harvard.edu.ORCID http://orcid.org/0000-0002-6110-4626
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA, USA. cbdm@hms.harvard.edu.ORCID http://orcid.org/0000-0003-1172-6555
Inserm · FRBoston Children's Hospital · USHarvard University · USBrigham and Women's Hospital · USMarmara University · TRNecmettin Erbakan University · TRUniversity of California, Los Angeles · USUniversity of Utah · US
Funding
Mechanisms of Disease Pathogenesis in Regulatory T cell DeficiencyR01AI085090 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHATILA, TALAL AMINE, WILLIAMS, CALVIN B · 2010 to 2020
$3.9MTreg cell diversity and homeostatic controlR01AI150686 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2020 to 2024
$2.6MSpecification of Treg cells: FOXP3 functional facetsR01AI116834 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2015 to 2019
$2.3MReprogramming of Regulatory T cells to Promote Immune ToleranceR01AI153174 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHARBONNIER, LOUIS-MARIE · 2020 to 2024
$2.2MT regulatory cell subsets at the microbial interface: determinism and functionR01AI125603 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2017 to 2021
$2.1MMechanisms of Combined Immunodeficiency due to DOCK8 DeficiencyR01AI128976 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE · 2018 to 2021
$1.4MNIAID NIH HHS R01 AI085090NIAID NIH HHS R01 AI116834NIAID NIH HHS R01 AI125603NIAID NIH HHS R01 AI128976NIAID NIH HHS R01 AI150686NIAID NIH HHS R01 AI153174
Abstract
FOXP3 deficiency in mice and in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome results in fatal autoimmunity by altering regulatory T (T
Indexed as
AdolescentAnimalsCase-Control StudiesChildChild, PreschoolCohort StudiesDatasets as TopicDiabetes Mellitus, Type 1DiarrheaDisease Models, AnimalFlow CytometryForkhead Transcription FactorsGenetic Diseases, X-LinkedHumansImmune System DiseasesInfantForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.