ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
Dysregulation of threat neurociruitry during fear extinction: the role of anhedonia.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis.Dialogues in clinical neuroscience · 2026Pooled it
- What good are positive emotions for treatment? A replication test of whether trait positive emotionality predicts response to exposure therapy for social anxiety disorder.Behaviour research and therapy · 2023Trial
- The Differential Relation of Emotional, Physical, and Sexual Abuse Histories to Antidepressant Treatment Remission and Persistence of Anhedonia in Major Depression: A CAN-BIND-1 Report.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Trial
- Functional connectivity during positive mood and anxiety treatment response in children.Journal of affective disorders · 2026Article
- Low Reward and Heightened Threat Neural Activity are Both Associated with Heightened Anhedonia: A Transdiagnostic Perspective.Research square · 2026Article
- Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology.Development and psychopathology · 2025Article
- Current State of the Neuroscience of Fear Extinction and Its Relevance to Anxiety Disorders.Current topics in behavioral neurosciences · 2025Review
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- Integrating threat conditioning and the hierarchical taxonomy of psychopathology to advance the study of anxiety-related psychopathology.Journal of psychopathology and clinical science · 2024Review
- Reward processes in extinction learning and applications to exposure therapy.Journal of anxiety disorders · 2024Review
- Anhedonia is associated with overgeneralization of conditioned fear during late adolescence and early adulthood.Journal of anxiety disorders · 2024Article
- Transdiagnostic symptom of depression and anxiety associated with reduced gray matter volume in prefrontal cortex.Psychiatry research. Neuroimaging · 2024Article
- Major stress in early childhood strengthens the association between peripheral inflammatory activity and corticostriatal responsivity to reward.Brain, behavior, and immunity · 2024Article
- Neural sensitivity following stress predicts anhedonia symptoms: a 2-year multi-wave, longitudinal study.Translational psychiatry · 2024Article
- Broadening the scope: Multiple functional connectivity networks underlying threat conditioning and extinction.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Predicting Fear Extinction in Posttraumatic Stress Disorder.Brain sciences · 2023Article
- Neural Sensitivity following Stress Predicts Anhedonia Symptoms: A 2-Year Multi-wave, Longitudinal Study.Research square · 2023Article
- Beyond Fear, Extinction, and Freezing: Strategies for Improving the Translational Value of Animal Conditioning Research.Current topics in behavioral neurosciences · 2023Article
- Association between reward-related functional connectivity and tri-level mood and anxiety symptoms.NeuroImage. Clinical · 2023Article
- Neural Processing Dysfunctions During Fear Learning but Not Reward-Related Processing Characterize Depressed Individuals With High Levels of Repetitive Negative Thinking.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Dimensional models of anxiety and depression highlight common and distinct symptom clusters that are thought to reflect disruptions in underlying functional processes. The current study investigated how functioning of threat neurocircuitry relates to symptom dimensions of anxiety and depression. Participants were aged 18-19 years (n = 229, 158 female) and were selected to ensure a range of scores on symptom measures. Symptom dimensions of "General Distress" (common to anxiety disorders and depression), "Fears" (more specific to anxiety disorders), and "Anhedonia-apprehension" (more specific to depression) were evaluated. Participants underwent functional magnetic resonance imaging during a Pavlovian fear conditioning paradigm. Multilevel modeling analyses estimated relationships between symptom dimensions and activation in threat neural circuitry. Exploratory whole brain analyses were also conducted. Threat-related neural activity was not associated with General Distress or Fears. Anhedonia-apprehension was associated with activation of bilateral amygdala, anterior insula and dACC during late extinction. We found no evidence to support an association between symptom dimensions of General Distress or Fears with threat circuitry activation in a large sample of young adults. We did, however, find that the symptom dimension of Anhedonia-apprehension was significantly associated with threat-related neural activation during fear extinction. This effect requires replication in future work but may reflect anhedonic impairments in learning when contingencies are altered, possibly linked to the rewarding relief of an unexpectedly absent threat.
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