ArticleScientific reports2021
Basmisanil, a highly selective GABA
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAJournal of neurodevelopmental disorders · 2022Trial
- A Comparison of Positive and Negative Allosteric Modulators of α5-Containing GABABiological psychiatry · 2026Review
- Excess EEG beta-band oscillations in Dup15q syndrome correlate with clinical severity.Translational psychiatry · 2026Article
- Dup15q model mice exhibit impaired gastrointestinal motility and a constipation-like phenotype, alleviated by prucalopride.Translational psychiatry · 2026Article
- Novel positive allosteric modulators of alpha 5 subunit-containing GABASchizophrenia research · 2026Article
- Multiplexed changes in synaptic transmission underlie stress-induced reduction of persistent firing in the parietal cortex.Progress in neurobiology · 2026Article
- Targeting γ-aminobutyric acid type A receptors to mitigate perioperative neurocognitive disorders: a narrative review.British journal of anaesthesia · 2026Review
- RO4938581, a GABAMolecular psychiatry · 2026Article
- Negative allosteric modulation of α5-GABAbioRxiv : the preprint server for biology · 2026Article
- GABAFrontiers in pharmacology · 2026Review
- Direct modulation of human GABA-A αFrontiers in neuroscience · 2026Review
- Benchmarking the utility of dry-electrode electroencephalography for clinical trials.Scientific reports · 2025Article
- Article
- Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia.EBioMedicine · 2025Article
- GREEN: A lightweight architecture using learnable wavelets and Riemannian geometry for biomarker exploration with EEG signals.Patterns (New York, N.Y.) · 2025Article
- Preclinical pharmacology of alogabat: a novel GABAFrontiers in pharmacology · 2025Article
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- Machine learning of brain-specific biomarkers from EEG.EBioMedicine · 2024Article
- Cognitive dysfunction in schizophrenia patients caused by down-regulation of γ-aminobutyric acid receptor subunits.World journal of psychiatry · 2024Article
- Basmisanil, an α5-GABANeuroscience letters · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 4 institutions in 3 countries.
Joerg F HippNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Frederic KnoflachNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Robert ComleyNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Theresa M BallardNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Michael HonerNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Gerhard TrubeNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Rodolfo GasserPharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Eric PrinssenNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Tanya L WallaceCNS Research, Roche Bioscience, Palo Alto, USA.
Andreas RothfussPharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Henner KnustSmall Molecule Research, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Sian Lennon-ChrimesPharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, AL7 1TW, UK.
Michael DerksPharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, AL7 1TW, UK.
Darren BentleyPharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, AL7 1TW, UK.
Lisa SquassanteNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Stephane NaveNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Jana NöldekeNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Christoph WandelPharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Andrew W ThomasSmall Molecule Research, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Maria-Clemencia HernandezNeuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. maria-clemencia.hernandez@roche.com.
Roche (Switzerland) · CHRoche (United Kingdom) · GBAbbVie (United States) · USCNS Research (United States) · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABA
Indexed as
Allosteric RegulationAnimalsBrainFemaleGABA-A Receptor AgonistsHealthy VolunteersHEK293 CellsHumansLearningMacaca fascicularisPositron-Emission TomographyRadioligand AssayRatsRats, Sprague-DawleyReceptors, GABA-AXenopus laevisGABA-A Receptor AgonistsReceptors, GABA-A
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.