ArticleScientific reports2021
Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Novel mechanisms of chemosensory adaptation to the cave environment.bioRxiv : the preprint server for biology · 2026Article
- Hagfish olfactory repertoire illuminates lineage-specific diversification of olfaction in basal vertebrates.iScience · 2025Article
- Natural variability of trace-amine associated receptors in wild meerkats.Frontiers in zoology · 2025Article
- Genome-wide identification, expression analysis of taars (trace amine-associated receptors) and response to cadaverine and putrescine in Mandarin fish (Siniperca chuatsi).BMC genomics · 2025Article
- Role of Glial Trace Amine Associated Receptor 1 (TAAR1) and Microbiota in Schizophrenia.Neurochemical research · 2025Review
- Behavioral, Endocrine, and Neuronal Responses to Odors in Lampreys.Animals : an open access journal from MDPI · 2025Review
- TAAR8 in the Brain: Implications for Dopaminergic Function, Neurogenesis, and Behavior.Biomedicines · 2025Article
- Structural Rearrangement of the Olfactory Epithelium in Male Baikal Yellowfin Sculpins Across the Reproductive Period.Biology · 2025Article
- Article
- Olfactory GPCRs through the lens of structural bioinformatics.Chemical senses · 2025Review
- The Sensory Shark: High-quality Morphological, Genomic and Transcriptomic Data for the Small-spotted Catshark Scyliorhinus Canicula Reveal the Molecular Bases of Sensory Organ Evolution in Jawed Vertebrates.Molecular biology and evolution · 2024Article
- Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024Review
- Diversity and evolution of the vertebrate chemoreceptor gene repertoire.Nature communications · 2024Article
- Structure-Based Discovery of Mouse Trace Amine-Associated Receptor 5 Antagonists.Journal of chemical information and modeling · 2023Article
- Ancient and Nonuniform Loss of Olfactory Receptor Expression Renders the Shark Nose a De Facto Vomeronasal Organ.Molecular biology and evolution · 2023Article
- Potential for host-symbiont communication via neurotransmitters and neuromodulators in an aneural animal, the marine spongeFrontiers in neural circuits · 2023Article
- Coevolution of the olfactory organ and its receptor repertoire in ray-finned fishes.BMC biology · 2022Article
- Evolution of Brain-Expressed Biogenic Amine Receptors into Olfactory Trace Amine-Associated Receptors.Molecular biology and evolution · 2022Article
- An Ancient Adenosine Receptor Gains Olfactory Function in Bony Vertebrates.Genome biology and evolution · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory receptor families have arisen independently several times during evolution. The origin of taar genes, one of the four major vertebrate olfactory receptor families, is disputed. We performed a phylogenetic analysis making use of 96 recently available genomes, and report that olfactory functionality has arisen twice independently within the TAAR family, once in jawed and once in jawless fish. In lamprey, an ancestral gene expanded to generate a large family of olfactory receptors, while the sister gene in jawed vertebrates did not expand and is not expressed in olfactory sensory neurons. Both clades do not exhibit the defining TAAR motif, and we suggest naming them taar-like receptors (tarl). We have identified the evolutionary origin of both taar and tarl genes in a duplication of the serotonergic receptor 4 that occurred in the most recent common ancestor of vertebrates. We infer two ancestral genes in bony fish (TAAR12, TAAR13) which gave rise to the complete repertoire of mammalian olfactory taar genes and to class II of the taar repertoire of teleost fish. We follow their evolution in seventy-one bony fish genomes and report a high evolutionary dynamic, with many late gene birth events and both early and late gene death events.
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