ArticleScientific reports2021
Neuromuscular fatigue and recovery after strenuous exercise depends on skeletal muscle size and stem cell characteristics.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Effects of Resistance Training to Muscle Failure on Acute Fatigue: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Comparison of post-isometric relaxation and active static stretching in improving hamstring flexibility among allied health sciences students: a randomized controlled trial.Scientific reports · 2026Trial
- Repeated sprint training: The effects of session volume on acute physiological, neuromuscular, perceptual and performance outcomes in athletes.European journal of sport science · 2025Trial
- Improved Strength Recovery and Reduced Fatigue with Suppressed Plasma Myostatin Following Supplementation of aNutrients · 2023Trial
- Peripheral Neuromuscular Fatigue Responses of the Knee Extensors to Distinct Concurrent Training Protocols: A Preliminary Study.Journal of functional morphology and kinesiology · 2026Article
- Impact of post-match fatigue on peak force in elite youth soccer players: Analysis of 48 to 72 hours post-match using the isometric mid-thigh pull exercise.Biology of sport · 2025Article
- Multi-scale modeling and simulation of skeletal muscles with different fatigue degrees based on microphysiology.Scientific reports · 2025Article
- Muscle soreness but not neuromuscular fatigue responses following downhill running differ according to the number of exercise bouts.European journal of sport science · 2025Article
- Assessment Methods of Sport-Induced Neuromuscular Fatigue: A Scoping Review.International journal of sports physical therapy · 2025Article
- From Tissue to System: What Constitutes an Appropriate Response to Loading?Sports medicine (Auckland, N.Z.) · 2025Review
- Immediate but not prolonged effects of submaximal eccentric vs concentric fatiguing protocols on the etiology of hamstrings' motor performance fatigue.European journal of applied physiology · 2024Article
- Effect of HY7602 Fermented Deer Antler on Physical Fatigue and Antioxidant Activity in Mice.International journal of molecular sciences · 2024Article
- Fatigue effects on the knee flexors neuromuscular parameters during repeated sprinting.BMC sports science, medicine & rehabilitation · 2024Article
- Article
- Biomolecules of Muscle Fatigue in Metabolic Myopathies.Biomolecules · 2023Review
- Effects of repeated sprinting on hamstring shear modulus pattern and knee flexor neuromuscular parameters.Scientific reports · 2023Article
- Article
- Assessment of inter-individual variability in hamstring muscle recovery after a sport-specific sprint training in women and men.Frontiers in physiology · 2023Article
- Effects of Fatigue Induced by Repeated Sprints on Sprint Biomechanics in Football Players: Should We Look at the Group or the Individual?International journal of environmental research and public health · 2022Article
- Is the Rotatory Knee Stability Immediately Decreased Following a Competitive Soccer Match?Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Hamstring muscle injury is highly prevalent in sports involving repeated maximal sprinting. Although neuromuscular fatigue is thought to be a risk factor, the mechanisms underlying the fatigue response to repeated maximal sprints are unclear. Here, we show that repeated maximal sprints induce neuromuscular fatigue accompanied with a prolonged strength loss in hamstring muscles. The immediate hamstring strength loss was linked to both central and peripheral fatigue, while prolonged strength loss was associated with indicators of muscle damage. The kinematic changes immediately after sprinting likely protected fatigued hamstrings from excess elongation stress, while larger hamstring muscle physiological cross-sectional area and lower myoblast:fibroblast ratio appeared to protect against fatigue/damage and improve muscle recovery within the first 48 h after sprinting. We have therefore identified novel mechanisms that likely regulate the fatigue/damage response and initial recovery following repeated maximal sprinting in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.