ArticleScientific reports2021
Telomere length and epigenetic age acceleration in adolescents with anxiety disorders.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Using Epigenetic Clocks to Characterize Biological Aging in Studies of Children and Childhood Exposures: a Systematic Review.Prevention science : the official journal of the Society for Prevention Research · 2023Pooled it
- Epigenetic Age Accelerations and the Clinical Presentation of Bipolar Disorders: A Latent Profile Analysis in the FACE-BD Sample.Bipolar disorders · 2026Article
- Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026Article
- Methylome-wide association study in blood suggests cell type-specific relationships between DNA methylation and lifetime anxiety.Nature communications · 2026Article
- Telomere length in youth with type 1 diabetes and the role of physical fitness.Pediatric research · 2025Article
- Child and adolescent internalizing and externalizing traits, and epigenetic summary scores: A scoping review.Biological psychology · 2025Article
- Early-Life Adversity and Epigenetic Aging: Findings from a 17-Year Longitudinal Study.Biomolecules · 2025Article
- The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Psychogenic Aging: A Novel Prospect to Integrate Psychobiological Hallmarks of Aging.Translational psychiatry · 2024Review
- Associations of depression and anxiety symptoms in childhood and adolescence with epigenetic aging.Journal of affective disorders · 2024Article
- The Social Environment Matters for Telomere Length and Internalizing Problems During Adolescence.Journal of youth and adolescence · 2024Article
- Robust evidence supports a causal link between higher birthweight and longer telomere length: a mendelian randomization study.Frontiers in genetics · 2024Article
- Associations of depression and anxiety and adolescent telomere length.Psychoneuroendocrinology · 2023Article
- Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Epigenomic Links Between Social Determinants of Health and Symptoms: A Scoping Review.Biological research for nursing · 2023Article
- A healthy lifestyle is positively associated with mental health and well-being and core markers in ageing.BMC medicine · 2022Article
- Interrelationships and determinants of aging biomarkers in cord blood.Journal of translational medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.