Evidence map›Paper›PMID 33833224›Full record

ArticleTranslational psychiatry2021

Subgenual cingulate resting regional cerebral blood flow in premenstrual dysphoric disorder: differential regulation by ovarian steroids and preliminary evidence for an association with expression of ESC/E(Z) complex genes.

Shau-Ming Wei, Erica B Baller, Pedro E Martinez, Allison C Goff, Howard J Li, Philip D Kohn, J Shane Kippenhan, Steven J Soldin, David R Rubinow, David Goldman and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Shau-Ming WeiSection on Integrative Neuroimaging, Clinical and Translational Neuroscience Branch, NIMH IRP, NIH, Bethesda, MD, USA.
Erica B BallerSection on Integrative Neuroimaging, Clinical and Translational Neuroscience Branch, NIMH IRP, NIH, Bethesda, MD, USA.ORCID 0000-0002-7987-3773
Pedro E MartinezBehavioral Endocrinology Branch; NIMH IRP, NIH, Bethesda, MD, USA.
Allison C GoffLaboratory of Neurogenetics, NIAAA, Bethesda, MD, USA.ORCID 0000-0002-1557-618X
Howard J LiLaboratory of Neurogenetics, NIAAA, Bethesda, MD, USA.
Philip D KohnSection on Integrative Neuroimaging, Clinical and Translational Neuroscience Branch, NIMH IRP, NIH, Bethesda, MD, USA.
J Shane KippenhanSection on Integrative Neuroimaging, Clinical and Translational Neuroscience Branch, NIMH IRP, NIH, Bethesda, MD, USA.
Steven J SoldinDepartment of Laboratory Medicine, NIH Clinical Center, Bethesda, MD, USA.
David R RubinowDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
David GoldmanLaboratory of Neurogenetics, NIAAA, Bethesda, MD, USA.ORCID 0000-0002-1724-5405
Peter J Schmidt *Behavioral Endocrinology Branch; NIMH IRP, NIH, Bethesda, MD, USA.
Karen F Berman *Section on Integrative Neuroimaging, Clinical and Translational Neuroscience Branch, NIMH IRP, NIH, Bethesda, MD, USA. karen.berman@nih.gov.
National Institutes of Health · USNational Institutes of Health Clinical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Integrative genetics of behavior with high throughput technologiesZIAAA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2025
$68.6M
Neuroimaging of Brain Circuits and Neurogenetic Mechanisms in Normal CognitionZIAMH002717 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BERMAN, KAREN FAITH · 2009 to 2024
$21.8M
Reproductive Endocrine Related Mood Disorders-Differential SensitivityZIAMH002865 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SCHMIDT, PETER · 2009 to 2025
$11.9M
The Neuroregulatory Effects of Gonadal Steroids in HumansZIAMH002874 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SCHMIDT, PETER · 2009 to 2024
$9.5M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Substantial evidence suggests that circulating ovarian steroids modulate behavior differently in women with PMDD than in those without this condition. However, hormonal state-related abnormalities of neural functioning in PMDD remain to be better characterized. In addition, while altered neural function in PMDD likely co-exists with alterations in intrinsic cellular function, such a relationship has not been explored. Here, we investigated the effects of ovarian steroids on basal, resting regional cerebral blood flow (rCBF) in PMDD, and, in an exploratory analysis, we tested whether the rCBF findings were linked to the expression of ESC/E(Z) genes, which form an essential ovarian steroid-regulated gene-silencing complex. Resting rCBF was measured with oxygen-15 water PET (189 PET sessions in 43 healthy women and 20 women with PMDD) during three self-as-own-control conditions: GnRH agonist (Lupron)-induced ovarian suppression, estradiol add-back, and progesterone add-back. ESC/E(Z) gene expression data were obtained from RNA-sequencing of lymphoblastoid cell lines performed in a previous study and were examined in relation to hormone-induced changes in rCBF. In the rCBF PET data, there was a significant diagnosis-by-hormone interaction in the subgenual cingulate (P

Indexed as

Premenstrual Dysphoric DisorderCerebrovascular CirculationEstradiolFemaleHumansProgesteroneSteroidsEstradiolProgesteroneSteroids

Identifiers

PMID33833224
PMCPMC8032707
OpenAlexW3143821099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.