ArticleScience (New York, N.Y.)2021
QSER1 protects DNA methylation valleys from de novo methylation.
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In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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0cells of the map it votes in
73citing papers in PubMed
–field-weighted citation impact
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Who cites it
73 citing papers in PubMed.
- A Comprehensive Review on CRISPR-Based Screening and Its Applications.Molecular biotechnology · 2026Review
- A progeria syndrome links DNA hypermethylation to age-related pathology.Nature genetics · 2026Article
- Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation.Developmental cell · 2026Article
- Functional chromatin signatures premark future lineage-specific enhancers.Cell genomics · 2026Article
- YAP1 and QSER1 are key modulators of embryonic signaling pathways in the mammalian epiblast.EMBO reports · 2026Article
- A distinct subclade of AlkB family demethylases in ciliates safeguards the positional fidelity of eukaryotic NProceedings of the National Academy of Sciences of the United States of America · 2026Article
- H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants.Nature communications · 2026Article
- Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylation.Nucleic acids research · 2026Article
- Learning genetic perturbation effects with variational causal inference.PLoS computational biology · 2026Article
- KAT6A regulates osteoclast differentiation and bone resorption through TET1-mediated TRPV4 expression.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Commensal Microbiota and Reproductive Health in Livestock: Mechanisms, Cross-System Crosstalk, and Precision Strategies.Animals : an open access journal from MDPI · 2026Review
- A stem cell knockout village reveals lineage rewiring and a non-canonical islet cell fate in monogenic diabetes.bioRxiv : the preprint server for biology · 2025Article
- Epigenetic regulatory mechanisms of autoimmune skin diseases: novel biomarkers and therapeutic prospects.Clinical epigenetics · 2025Review
- YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast.bioRxiv : the preprint server for biology · 2025Article
- Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells.Stem cell reports · 2025Article
- Learning Genetic Perturbation Effects with Variational Causal Inference.bioRxiv : the preprint server for biology · 2025Article
- Epigenetic signatures in surrogate tissues are able to assess cancer risk and indicate the efficacy of preventive measures.Communications medicine · 2025Article
- Histone bivalency in CNS development.Genes & development · 2025Review
- Stage-specific DNA methylation dynamics in mammalian heart development.Epigenomics · 2025Review
- The DNA demethylase TET1 modifies the impact of maternal folic acid status on embryonic brain development.EMBO reports · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors.
Gary Dixon *Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.ORCID https://orcid.org/0000-0002-6616-4740
Heng Pan *Department of Physiology and Biophysics, Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.ORCID https://orcid.org/0000-0002-5407-5687
Dapeng YangDevelopmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
Bess P RosenWeill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.ORCID https://orcid.org/0000-0003-1167-656X
Therande JashariWeill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.ORCID https://orcid.org/0000-0001-8874-7675
Nipun VermaDevelopmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
Julian PulecioDevelopmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.ORCID https://orcid.org/0000-0002-4455-8095
Inbal CaspiWeill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.ORCID https://orcid.org/0000-0003-1852-2643
Kihyun LeeDevelopmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.ORCID https://orcid.org/0000-0002-8754-4128
Stephanie StranskyDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID https://orcid.org/0000-0003-0844-2754
Abigail GlezerDevelopmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.ORCID https://orcid.org/0000-0002-2887-1225
Chang LiuDepartment of Chemistry, Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0001-5219-1089
Marco RivasDepartment of Chemistry, Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0002-7445-0341
Ritu KumarDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA.ORCID https://orcid.org/0000-0002-9995-0078
Yahui LanDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA.
Ingrid TorregrozaDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA.ORCID https://orcid.org/0000-0002-5368-0834
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0003-4319-7424
Simone SidoliDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID https://orcid.org/0000-0001-9073-6641
Todd EvansDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA.
Olivier ElementoDepartment of Physiology and Biophysics, Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. huangfud@mskcc.org ole2001@med.cornell.edu.ORCID https://orcid.org/0000-0002-8061-9617
Danwei HuangfuDevelopmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA. huangfud@mskcc.org ole2001@med.cornell.edu.ORCID https://orcid.org/0000-0002-1145-6199
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MLabeling and sequencing of 5hmC and 5mC in DNA-RenewalR01HG006827 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2012 to 2025
$7.2MTRAINING PROGRAM IN MOLECULAR AND CELLULAR BIOLOGYT32GM008539 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BROWN, ANTHONY M.C. · 1995 to 2020
$5.0MUnderstanding Pancreatic Progenitors for Diabetes Cell-Replacement TherapyR01DK096239 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI HUANGFU, DANWEI · 2012 to 2021
$4.4MTraining Program in Developmental BiologyT32HD060600 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BAO, ZHIRONG, STUHLMANN, HEIDI · 2010 to 2024
$3.5MNCI NIH HHS P30 CA008748NHGRI NIH HHS R01 HG006827NICHD NIH HHS T32 HD060600NIDDK NIH HHS R01 DK096239NIGMS NIH HHS T32 GM008539
Abstract
DNA methylation is essential to mammalian development, and dysregulation can cause serious pathological conditions. Key enzymes responsible for deposition and removal of DNA methylation are known, but how they cooperate to regulate the methylation landscape remains a central question. Using a knockin DNA methylation reporter, we performed a genome-wide CRISPR-Cas9 screen in human embryonic stem cells to discover DNA methylation regulators. The top screen hit was an uncharacterized gene,
Indexed as
DNA MethylationCRISPR-Cas SystemsDNADNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BEnhancer Elements, GeneticGene Expression Regulation, DevelopmentalGene Knock-In TechniquesGene Knockout TechniquesGenome, HumanHuman Embryonic Stem CellsHumansMixed Function OxygenasesPromoter Regions, GeneticProtein BindingDNADNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDNMT3A protein, humanMixed Function OxygenasesProto-Oncogene ProteinsTET1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.