Evidence map›Paper›PMID 33833059›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Reply to Liu et al.: Specific mutations matter in specificity and catalysis in ACE2.

Jeff Glasgow, Anum Glasgow, Tanja Kortemme, James A Wells

Abstract readLetterComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jeff GlasgowDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.ORCID 0000-0001-6699-8983
Anum GlasgowDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.ORCID 0000-0002-0938-881X
Tanja KortemmeDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158.
James A WellsDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158; jim.wells@ucsf.edu.ORCID 0000-0001-8267-5519

Funding

Mapping and rewiring protein allosteryR00GM135529 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GLASGOW, ANUM AZAM · 2022 to 2024
$747k
Mapping and rewiring protein allosteryK99GM135529 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASGOW, ANUM AZAM · 2020 to 2021
$194k
NIGMS NIH HHS K99 GM135529NIGMS NIH HHS R00 GM135529
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin-Converting Enzyme 2CatalysisMutationAngiotensin-Converting Enzyme 2

Identifiers

PMID33833059
PMCPMC8053976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.