Evidence map›Paper›PMID 33832966›Full record

ArticleAnnals of the rheumatic diseases2021

EULAR Points to Consider (PtC) for designing, analysing and reporting of studies with work participation as an outcome domain in patients with inflammatory arthritis.

Annelies Boonen, Polina Putrik, Mary Lucy Marques, Alessia Alunno, Lydia Abasolo, Dorcas Beaton, Neil Betteridge, Mathilda Bjørk, Maarten Boers, Boryana Boteva and 13 more

Open access · hybridAbstract read
In one paragraph

Article in Annals of the rheumatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. The Work Productivity and Activity Impairment (WPAI) questionnaire.Occupational medicine (Oxford, England) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 19 institutions in 11 countries.

Annelies BoonenDivision of Rheumatology, Maastricht University Medical Centre+ Internal Medicine, Maastricht, The Netherlands a.boonen@mumc.nl.ORCID 0000-0003-0682-9533
Polina PutrikDivision of Rheumatology, Maastricht University Medical Centre+ Internal Medicine, Maastricht, The Netherlands.ORCID 0000-0002-9342-1861
Mary Lucy MarquesRheumatologist, Leiden University Medical Center, Leiden, The Netherlands.
Alessia AlunnoRheumatology Unit, University of Perugia Department of Medicine, Perugia, Italy.ORCID 0000-0003-1105-5640
Lydia AbasoloDepartment of Rheumatology, Instituto de Investigation Sanitaria San Carlos, Hospital Clinico Universitario San Carlos, Madrid, Spain.
Dorcas BeatonMobility Program Clinical Research Unit, St Michael's Hospital Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada.
Neil BetteridgeNeil Betteridge Associates, London, UK.
Mathilda BjørkPain and Rehabilitation Center, and Department of Health, Medicine and Caring Sciences, Linköping University, Linkoping, Sweden.ORCID 0000-0002-1607-187X
Maarten BoersDepartment of Epidemiology and Data Science; Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-6969-283X
Boryana BotevaPatients with Arthritis and Rheumatism (PARE) working group, European League Against Rheumatism, Zurich, Switzerland.
Bruno FautrelPEPITES teams, Pierre Louis Institute for Epidemiology and Public Health, Inserm UMR 1136, Paris, France.ORCID 0000-0001-8845-4274
Francis GuilleminAPEMAC, Université de Lorraine, Nancy, France.
Elsa F MateusPortuguese League Against Rheumatic Diseases (LPCDR) and Comprehensive Health Research Centre (CHRC), Lisbon, Portugal.
Elena NikiphorouCentre for Rheumatic Diseases, King's College of London, London, UK.ORCID 0000-0001-6847-3726
Márta PéntekHealth Economics Research Center, University Research and Innovation Center, Óbuda University, Budapest, Hungary.
Fernando Pimentel SantosRheumatology Department, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal.
Johannes L SeverensErasmus School of Health Policy & Management and iMTA, Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Suzanne M M VerstappenCentre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Karen Walker-BoneMRC Versus Arthritis Centre for Musculoskeletal Health and Work, MRC Life course Epidemiology Unit, Southampton General Hospital, Southampton, UK.
Johan Karlsson WallmanDepartment of Clinical sciences, Lund University, Lund, Sweden.ORCID 0000-0002-4915-2924
Marieke M Ter WeeDepartment of Epidemiology and Data Science, Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
René WesthovensDept of Rheumatology, KU Leuven University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-3432-3073
Sofia RamiroRheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-8899-9087
Amsterdam University Medical Centers · NLInserm · FRLeiden University Medical Center · NLMaastricht University Medical Centre · NLErasmus University Rotterdam · NLEuropean League Against Rheumatism · CHHospital Clínico San Carlos · ESHospital de Egas Moniz · PTKing's College London · GBKU Leuven · BELinköping University · SELund University · SEManchester Academic Health Science Centre · GBMore Associates · GBObuda University · HUPortuguese League Against Epilepsy · PTSouthampton General Hospital · GBSt. Michael's Hospital · CAUniversity of Perugia · IT

Funding

Medical Research Council MC_PC_15015Medical Research Council MC_PC_21002
6 · The paper itself

Abstract

backgroundClinical studies with work participation (WP) as an outcome domain pose particular methodological challenges that hamper interpretation, comparison between studies and meta-analyses.

objectivesTo develop Points to Consider (PtC) for design, analysis and reporting of studies of patients with inflammatory arthritis that include WP as a primary or secondary outcome domain.

methodsThe EULAR Standardised Operating Procedures were followed. A multidisciplinary taskforce with 22 experts including patients with rheumatic diseases, from 10 EULAR countries and Canada, identified methodologic areas of concern. Two systematic literature reviews (SLR) appraised the methodology across these areas. In parallel, two surveys among professional societies and experts outside the taskforce sought for additional methodological areas or existing conducting/reporting recommendations. The taskforce formulated the PtC after presentation of the SLRs and survey results, and discussion. Consensus was obtained through informal voting, with levels of agreement obtained anonymously.

resultsTwo overarching principles and nine PtC were formulated. The taskforce recommends to align the work-related study objective to the design, duration, and outcome domains/measurement instruments of the study (PtC: 1-3); to identify contextual factors upfront and account for them in analyses (PtC: 4); to account for interdependence of different work outcome domains and for changes in work status over time (PtC: 5-7); to present results as means as well as proportions of patients reaching predefined meaningful categories (PtC: 8) and to explicitly report volumes of productivity loss when costs are an outcome (PtC:9).

conclusionAdherence to these EULAR PtC will improve the methodological quality of studies evaluating WP.

Indexed as

ArthritisEmploymentOutcome Assessment, Health CareWorkWork EngagementAdvisory CommitteesData AnalysisEuropeGuidelines as TopicHumansResearch DesignResearch ReportSocieties, Medicalankylosingarthritishealth careoutcome and process assessmentpsoriaticrheumatoidspondylitis

Identifiers

PMID33832966
PMCPMC8372378
OpenAlexW3145440935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.