Evidence map›Paper›PMID 33832502›Full record

ArticleBMC biology2021

The reference genome and transcriptome of the limestone langur, Trachypithecus leucocephalus, reveal expansion of genes related to alkali tolerance.

Tengcheng Que, Huifeng Wang, Weifei Yang, Jianbao Wu, Chenyang Hou, Surui Pei, Qunying Wu, Liu Ming Li, Shilu Wei, Xing Xie and 30 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 5 institutions in 1 country.

Tengcheng Que *Terrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Huifeng Wang *Department of Biochemistry and Molecular Biology, School of Pre-Clinical Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Weifei Yang *Annoroad Gene Technology, Beijing, 100176, China.
Jianbao Wu *Guangxi Chongzuo white headed langur national nature reserve, Chongzuo, Guangxi, 532200, China.
Chenyang Hou *School of Information and Management, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Surui PeiAnnoroad Gene Technology, Beijing, 100176, China.
Qunying WuDepartment of Biochemistry and Molecular Biology, School of Pre-Clinical Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Liu Ming LiGuangxi Reproductive Medical Research Center, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Shilu WeiLife Sciences Institute, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Xing XieLife Sciences Institute, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Hongli HuangLife Sciences Institute, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Panyu ChenTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Yiming HuangCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Aiqiong WuTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Meihong HeTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Dengpan NongTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Xiao WeiGuangxi Chongzuo white headed langur national nature reserve, Chongzuo, Guangxi, 532200, China.
Junyi WuNanning Animal Zoo, Nanning, Guangxi, 530021, China.
Ru NongNanning Animal Zoo, Nanning, Guangxi, 530021, China.
Ning HuangNanning Animal Zoo, Nanning, Guangxi, 530021, China.
Qingniao ZhouDepartment of Biochemistry and Molecular Biology, School of Pre-Clinical Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Yaowang LinDepartment of Biochemistry and Molecular Biology, School of Pre-Clinical Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Tingxi LuSchool of Information and Management, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Yongjie WeiTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Shousheng LiTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Jianglong YaoTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Yanli ZhongTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Huayong QinTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Luohao TanTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Yingjiao LiTerrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, Guangxi, 530003, China.
Weidong LiLife Sciences Institute, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Tao LiuAnnoroad Gene Technology, Beijing, 100176, China.
Sanyang LiuAnnoroad Gene Technology, Beijing, 100176, China.
Yongyi YuAnnoroad Gene Technology, Beijing, 100176, China.
Hong QiuAnnoroad Gene Technology, Beijing, 100176, China.
Yonghua JiangCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Youcheng LiLife Sciences Institute, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Zhijin LiuCollege of Life Sciences, Capital Normal University, Beijing, 100048, China.
Cheng Ming HuangCollege of Life Sciences, Capital Normal University, Beijing, 100048, China. cmhuang@ioz.ac.cn.
Yanling HuDepartment of Biochemistry and Molecular Biology, School of Pre-Clinical Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, China. huyanling@gxmu.edu.cn.
Guangxi Medical University · CNGuangxi Center for Disease Prevention and Control · CNAnnoroad Gene Technology (China) · CNFanjingshan National Nature Reserve · CNCapital Normal University · CN

Funding

by the National Natural Science Foundation of China No.31672285Guangxi Forestry Department Foundation No. 2017001 and No. 2016007National Natural Science Foundation of China No. 81472414
6 · The paper itself

Abstract

backgroundTrachypithecus leucocephalus, the white-headed langur, is a critically endangered primate that is endemic to the karst mountains in the southern Guangxi province of China. Studying the genomic and transcriptomic mechanisms underlying its local adaptation could help explain its persistence within a highly specialized ecological niche.

resultsIn this study, we used PacBio sequencing and optical assembly and Hi-C analysis to create a high-quality de novo assembly of the T. leucocephalus genome. Annotation and functional enrichment revealed many genes involved in metabolism, transport, and homeostasis, and almost all of the positively selected genes were related to mineral ion binding. The transcriptomes of 12 tissues from three T. leucocephalus individuals showed that the great majority of genes involved in mineral absorption and calcium signaling were expressed, and their gene families were significantly expanded. For example, FTH1 primarily functions in iron storage and had 20 expanded copies.

conclusionsThese results increase our understanding of the evolution of alkali tolerance and other traits necessary for the persistence of T. leucocephalus within an ecologically unique limestone karst environment.

Indexed as

ColobinaeAlkaliesAnimalsChinaGenomePresbytiniTranscriptomeAlkaliesAlkali toleranceGenome assemblyLimestone karstsMineral ion bindingTrachypithecus leucocephalus

Identifiers

PMID33832502
PMCPMC8034193
OpenAlexW3145607525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.