Evidence map›Paper›PMID 33832460›Full record

ArticleBMC infectious diseases2021

Co-infection of HIV in patients with Buruli ulcer disease in Central Ghana.

Yaw Ampem Amoako, Aloysius Dzigbordi Loglo, Michael Frimpong, Bernadette Agbavor, Mohammed Kabiru Abass, George Amofa, Elizabeth Ofori, Edwin Ampadu, Kingsley Asiedu, Ymkje Stienstra and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Case Report ofCase reports in infectious diseases · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Yaw Ampem AmoakoSchool of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. yamoako2002@yahoo.co.uk.
Aloysius Dzigbordi LogloSchool of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Michael FrimpongSchool of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Bernadette AgbavorSchool of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Mohammed Kabiru AbassAgogo Presbyterian Hospital, Agogo, Ghana.
George AmofaDunkwa Government Hospital, Dunkwa, Ghana.
Elizabeth OforiTepa Government Hospital, Tepa, Ghana.
Edwin AmpaduNational Buruli ulcer Control Programme, Ghana Health Service, Accra, Ghana.
Kingsley AsieduDepartment of Neglected Tropical Diseases, WHO, Geneva, Switzerland.
Ymkje StienstraDepartment of Medicine/ Infectious Diseases, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands.
Mark Wansbrough-JonesInstitute of Infection and Immunity, St George's University of London, London, UK.
Tjip van der WerfDepartment of Medicine/ Infectious Diseases, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands.
Richard Odame PhillipsSchool of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Kwame Nkrumah University of Science and Technology · GHKumasi Centre for Collaborative Research in Tropical Medicine · GHUniversity Medical Center Groningen · NLDrugs for Neglected Diseases Initiative · CHGhana Education Service · GHGhana Health Service · GHPresbyterian University, Ghana · GHSt George's, University of London · GBUniversity of Mines and Technology · GH

Funding

Medical Research Council MR/J01477X/1World Health Organization 001
6 · The paper itself

Abstract

backgroundPrevious studies have reported that presence and severity of Buruli ulcer (BU) may reflect the underlying immunosuppression in HIV infected individuals by causing increased incidence of multiple, larger and ulcerated lesions. We report cases of BU-HIV coinfection and the accompanying programmatic challenges encountered in central Ghana.

methodsPatients with PCR confirmed BU in central Ghana who were HIV positive were identified and their BU01 forms were retrieved and reviewed in further detail. A combined 16S rRNA reverse transcriptase / IS2404 qPCR assay was used to assess the Mycobacterium ulcerans load. The characteristics of coinfected patients (BU

resultsThe prevalence of HIV in this BU cohort was 2.4% (compared to national HIV prevalence of 1.7%). Eight of 9 BU

conclusionThe prevalence of HIV in the BU+ infected population was not significantly increased when compared to the prevalence of HIV in the general population. There was no clear relationship between BU lesion severity and HIV viral load or CD4 counts. Efforts should be made to encourage the integration of care of patients with BU-HIV coinfection.

Indexed as

AdolescentAdultBacterial LoadBuruli UlcerCD4 Lymphocyte CountCoinfectionFemaleGhanaHIV InfectionsHumansMaleMiddle AgedMycobacterium ulceransPrevalenceReal-Time Polymerase Chain ReactionRetrospective StudiesRNA, Ribosomal, 16SAntiretroviral therapyBuruli ulcerCoinfectionHuman immunodeficiency syndromeImmune reconstitution syndromeInterferon-gammaMycolactoneParadoxical reaction

Identifiers

PMID33832460
PMCPMC8028811
OpenAlexW3148898057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.