Evidence map›Paper›PMID 33832425›Full record

SynthesisBMC gastroenterology2021

Gastrointestinal symptoms as first remarkable signs of ANCA-associated granulomatosis with polyangiitis: a case report and reviews.

Nóra Ledó, Ákos Géza Pethő

Open access · goldAbstract readCase ReportsSystematic Review
In one paragraph

Synthesis in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. A Case of Granulomatosis with Polyangiitis Masquerading as Community Acquired Pneumonia.Journal of community hospital internal medicine perspectives · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Novel pediatric granulomatosis with polyangiitis with a marked bloody pericardial effusion and bloody stool: a case report.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nóra LedóDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary. ledo.nora@med.semmelweis-univ.hu.ORCID http://orcid.org/0000-0002-2439-9218
Ákos Géza PethőDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0001-9776-9841
Semmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSystemic vasculitis associated with antineutrophil cytoplasmic autoantibodies (ANCA) have an extremely wide variety of symptoms, therefore the fast and proper diagnosis is difficult to establish even for experienced physicians. Gastrointestinal manifestations in ANCA-associated granulomatosis with polyangiitis (GPA) may be present, however, severe, life-threatening complications (such as perforations) are rare. CASE PRESENTATION: A case of an 18-year-old male patient is presented, where gastrointestinal symptoms (abdominal pain, vomiting, diarrhoea) were the first remarkable signs of GPA. The initial diagnosis of inflammatory bowel disease delayed the administration of proper immunosuppressive therapy, which might have contributed to the rare and life-threatening complication of arterial duodenal bleeding with perforation. Our systematic review of the literature found only a few case reports where gastrointestinal symptoms were the first signs of GPA, however, this entity might be more frequent if physicians would think of this possibility more often.

conclusionsGastrointestinal bleeding is a rare but potential lethal complication of vasculitis. Consequently, we recommend investigating the patients diagnosed with GPA for gastrointestinal bleeding during the treatment.

Indexed as

Antibodies, Antineutrophil CytoplasmicGranulomatosis with PolyangiitisAdolescentAutoantibodiesHumansMaleAntibodies, Antineutrophil CytoplasmicAutoantibodiesAntineutrophil cytoplasmic antibodiesCase reportGastrointestinal haemorrhageGranulomatosis with polyangiitisSystemic vasculitis

Identifiers

PMID33832425
PMCPMC8028736
OpenAlexW3151359552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.