Observational studyMedicine2021
Nonadherence to antihypertensive medications amongst patients with uncontrolled hypertension: A retrospective study.
Observational study in Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Efficacy of a mobile health application on self-management among Japanese patients with chronic kidney disease.Clinical and experimental nephrology · 2025Trial
- Sex stratified analysis of patients with resistant hypertension from the Global SYMPLICITY Registry of renal denervation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- '4 Ss' for successful blood pressure control.Journal of hypertension · 2025Article
- Factors influencing self-report adherence to treatment in a sample of patients with hypertension in the west Pomeranian Voivodeship of Poland.Frontiers in public health · 2025Article
- A cross-sectional study on the assessment of adherence to cardiovascular medications in Sudan heart center.PloS one · 2025Article
- "Deeds not words": the forgotten class.Journal of human hypertension · 2024Review
- Factors Associated with Adherence to Medication among Hypertensive Patients in a District Hospital, Northern Province, Rwanda.Rwanda journal of medicine and health sciences · 2024Article
- Review
- Gender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health.Metabolites · 2023Review
- Prevalence and determinants of resistant hypertension in the delta region of Egypt: A prospective observational study.Health science reports · 2023Article
- Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems.Nature reviews. Drug discovery · 2023Review
- Opportunities of Amlodipine as a Potential Candidate in the Evaluation of Drug Compliance during Antihypertensive Therapy.Medicina (Kaunas, Lithuania) · 2023Article
- The therapeutic concordance approach reduces adverse drug reactions in patients with resistant hypertension.Frontiers in cardiovascular medicine · 2023Article
- Sex differences in arterial hypertension.European heart journal · 2022Review
- Comparison of Pharmacy Refill Data With Chemical Adherence Testing in Assessing Medication Nonadherence in a Safety Net Hospital Setting.Journal of the American Heart Association · 2022Article
- Medication Adherence and Treatment-Resistant Hypertension in Newly Treated Hypertensive Patients in the United Arab Emirates.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractMedication nonadherence represents a modifiable risk factor for patients with hypertension. Identification of nonadherent patients could have significant clinical and economic implications in the management of uncontrolled hypertension.We analysed the results of 174 urinary adherence screens from patients referred to Addenbrooke's Hospital, Cambridge, for uncontrolled hypertension. Cases were identified for evaluation by results of liquid chromatography-tandem mass spectrometry of urine samples (males: 91; females: 83; age range: 17-87). We performed a binary logistic regression analysis for nonadherence using age, sex, and number of medications prescribed (both antihypertensives and non-antihypertensives separately) as independent predictors. Rates of nonadherence for individual antihypertensive drugs were calculated if prescribed to ≥10 patients.The overall rate of nonadherence to one or more prescribed antihypertensive medications was 40.3%. 14.4% of all patients were nonadherent to all prescribed antihypertensive medications (complete nonadherence), whereas 25.9% of all patients were nonadherent to at least 1, (but not all) prescribed antihypertensive medications (partial nonadherence). 72% of patients were prescribed ≥3 antihypertensives And for every increase in the number of antihypertensive medications prescribed, nonadherence increased with adjusted odds ratios of 2.9 (P < .001). Logistic regression showed that women were 3.3 times more likely to be nonadherent (P = .004). Polypharmacy (≥6 medications prescribed for hypertension and/or concomitant comorbidities) was prevalent in 52%. Bendroflumethiazide and chlortalidone demonstrated the highest and lowest nonadherences respectively (45.5% and 11.8%).Rate of nonadherence in patients with hypertension was significantly impacted by sex and number of antihypertensive medications prescribed. Understanding these factors is crucial in identifying and managing nonadherence.
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