ArticleThe world journal of men's health2021
A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility.
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Article in The world journal of men's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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35citing papers in PubMed, 2 pooled it
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Pharmacologic and Nutritional Therapies in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis.Andrology · 2026Pooled it
- Systematic Review and Critical Analysis on Dietary Supplements for Male Infertility: From a Blend of Ingredients to a Rationale Strategy.Frontiers in endocrinology · 2021Pooled it
- Alpha-Lipoic Acid Supplementation for Male Partner of Couples with Recurrent Pregnancy Loss: A Post hoc analysis in Clinical Trial.International journal of fertility & sterility · 2023Trial
- Re-Imagining Male Infertility Guidelines through the Global Andrology Forum.The world journal of men's health · 2026Article
- Antioxidants and Nutraceutical for Male Factor Infertility: Where Does the Evidence Stand?Andrology · 2026Article
- Oxidative Stress, Sperm DNA Fragmentation, or Both? Optimizing Test Selection in Male Infertility Evaluation.Antioxidants (Basel, Switzerland) · 2026Review
- Redox-Genomic Crosstalk: Linking Oxidative Stress, Sperm DNA Fragmentation, and Epigenetics in Personalized Management of Male Infertility.Journal of personalized medicine · 2026Review
- Reductive stress and the role of antioxidants in male infertility: a narrative review.Archives of gynecology and obstetrics · 2025Review
- The Impact of Diabetes Mellitus-Related Oxidative Stress on Male Fertility: A Review.Journal of diabetes · 2025Review
- Evaluation of the effects of multiantioxidant therapy on sperm parameters, reproductive hormones, sperm DNA integrity, and pregnancy rates in infertile men with different grades of varicocele.Clinical and experimental reproductive medicine · 2025Article
- Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia.Frontiers in endocrinology · 2025Review
- Idiopathic male infertility - what are we missing?Arab journal of urology · 2025Article
- Revolutionizing Andrology: The Advent of the Global Andrology Forum, a Groundbreaking Initiative.The world journal of men's health · 2025Article
- Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future Perspectives.Genes · 2024Review
- Frequency, morbidity and equity - the case for increased research on male fertility.Nature reviews. Urology · 2024Review
- A family with normal sperm motility carrying a sY86 deletion in AZFa region and partial deletion in AZFc region.Frontiers in genetics · 2024Article
- Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects.Frontiers in endocrinology · 2024Review
- External quality assessment scheme for sperm DNA fragmentation: a pilot study in China.Basic and clinical andrology · 2023Article
- Effect of N-acetyl-L-cysteine on Testicular Tissue in Busulfan-Induced Dysfunction in the Male Reproductive System.The world journal of men's health · 2023Article
Corrections and comments
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Authors and funding
71 authors at 20 institutions in 38 countries.
Ashok AgarwalAmerican Center for Reproductive Medicine, Cleveland Clinic, Ohio, USA. agarwaa@ccf.org.ORCID https://orcid.org/0000-0003-0585-1026
Renata FinelliAmerican Center for Reproductive Medicine, Cleveland Clinic, Ohio, USA.ORCID https://orcid.org/0000-0002-5926-6407
Manesh Kumar Panner SelvamAmerican Center for Reproductive Medicine, Cleveland Clinic, Ohio, USA.ORCID https://orcid.org/0000-0002-9120-2278
Kristian LeisegangSchool of Natural Medicine, University of the Western Cape, South Africa.ORCID https://orcid.org/0000-0002-3003-8048
Ahmad MajzoubDepartment of Urology, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0001-7423-6241
Nicholas TadrosDivision of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.ORCID https://orcid.org/0000-0002-2272-235X
Edmund KoDepartment of Urology, Loma Linda University Health, Loma Linda, CA, USA.ORCID https://orcid.org/0000-0002-7465-3616
Neel ParekhDepartment of Urology, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-6218-9254
Ralf HenkelAmerican Center for Reproductive Medicine, Cleveland Clinic, Ohio, USA.ORCID https://orcid.org/0000-0003-1128-2982
Damayanthi DurairajanayagamFaculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia.ORCID https://orcid.org/0000-0001-9049-0215
Giovanni M ColpiAndrology and IVF Unit, Procrea Institute, Lugano, Switzerland.ORCID https://orcid.org/0000-0003-1431-1777
Chak Lam ChoS. H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong.ORCID https://orcid.org/0000-0003-2520-6833
Hassan N SallamAlexandria University Faculty of Medicine, Alexandria, Egypt.ORCID https://orcid.org/0000-0003-1308-6280
Hyun Jun ParkDepartment of Urology, Pusan National University School of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0003-0566-9574
Ramadan SalehDepartment of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.ORCID https://orcid.org/0000-0003-0503-3533
Sava MicicUromedica Polyclinic, Andrology Department, Belgrade, Serbia.ORCID https://orcid.org/0000-0001-9037-3318
Rafael F AmbarSexual and Reproductive Medicine, Department of Urology, Faculdade de Medicina do ABC, Santo André, Brazil.ORCID https://orcid.org/0000-0002-3496-2895
Armand ZiniDepartment of Surgery, McGill University, St. Mary's Hospital, Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-2194-5578
Kelton TremellenDepartment of Obstetrics Gynaecology and Reproductive Medicine, Flinders University, Bedford Park, South Australia.ORCID https://orcid.org/0000-0001-5575-6049
Juan G AlvarezCentro ANDROGEN, La Coruro, Spain.ORCID https://orcid.org/0000-0002-4851-9579
Ayad PalaniDepartment of Biochemistry, College of Medicine, University of Garmian, Kalar, Iraq.ORCID https://orcid.org/0000-0001-7806-9903
Mohamed ArafaAmerican Center for Reproductive Medicine, Cleveland Clinic, Ohio, USA.ORCID https://orcid.org/0000-0003-0107-8857
Marcello M GavaSexual and Reproductive Medicine, Department of Urology, Faculdade de Medicina do ABC, Santo André, Brazil.ORCID https://orcid.org/0000-0001-5760-7987
Sunil JindalDepartment of Andrology and Reproductive Medicine, Jindal Hospital, Meerut, India.ORCID https://orcid.org/0000-0002-8088-8710
Edouard AmarCabinet D'Andrologie Victor Hugo, American Hospital of Paris Reproductive Center, Paris, France.ORCID https://orcid.org/0000-0002-0617-8024
Zsolt KopaAndrology Centre, Department of Urology, Semmelweis University, Budapest, Hungary.ORCID https://orcid.org/0000-0001-5670-8647
Mohammad Reza MoeinYazd Research and Clinical Center for Infertility, Yazd, Iran.ORCID https://orcid.org/0000-0003-4487-4976
Gian Maria BusettoDepartment of Urology and Renal Transplantation, University of Foggia Policlinico Riuniti of Foggia, Foggia, Italy.ORCID https://orcid.org/0000-0002-7291-0316
Pallav SenguptaDepartment of Physiology, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0002-1928-5048
Parviz KavoussiAustin Fertility & Reproductive Medicine/Westlake IVF, Austin, TX, USA.ORCID https://orcid.org/0000-0001-7390-5837
Israel MaldonadoCitmer Reproductive Medicine, IVF LAB, Mexico City, Mexico.ORCID https://orcid.org/0000-0003-2765-6176
Jamal FikriIVF Unit, Al Boustane Clinic, Rabat, Morocco.ORCID https://orcid.org/0000-0002-1165-8858
Edson BorgesFertility Medical Group, Sapientiae Institute, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4971-1925
Marlon MartinezDepartment of Urology, University of Santo Tomas Hospital, Manila, Philippines.ORCID https://orcid.org/0000-0002-1191-8154
Djordje BojovicGAO Bojović, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-1166-8976
Osvaldo RajmilDeparment of Andrology, Fundacio Puigvert, Barcelona, Spain.ORCID https://orcid.org/0000-0003-1987-9206
Kaan AydosDepartment of Urology, University of Ankara, Ankara, Turkey.ORCID https://orcid.org/0000-0001-7691-5459
Sijo ParekattilAvant Concierge Urology & University of Central Florida, Winter Garden, FL, USA.ORCID https://orcid.org/0000-0001-6847-8826
Joel L MarmarHonorary Staff of Cooper University Hospital, Camden, NJ, USA.ORCID https://orcid.org/0000-0002-6158-7154
Omar SefriouiAnfa Fertility Center, Casablanca, Morocco.ORCID https://orcid.org/0000-0001-7721-8911
Andreas JungwirthSt. Barbara Clinic, Bad Vigaun, Austria.ORCID https://orcid.org/0000-0002-3954-9813
Marcelo Gabriel Rodriguez PeñaAndrology Unit, Instituto De Ginecologia y Fertilidad (IFER), Buenos Aires, Argentina.ORCID https://orcid.org/0000-0003-2437-7833
Emerson B CordtsInstituto Ideia Fertil-Human Reproduction Centre-Faculdade de Medicina do ABC, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0003-4933-4274
Haitham ElbardisiDepartment of Urology, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0003-3902-7924
Taymour MostafaDepartment of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-3627-0662
Marjan SabbaghianDepartment of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.ORCID https://orcid.org/0000-0001-9439-268X
Mohammad Ali Sadighi GilaniDepartment of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.ORCID https://orcid.org/0000-0001-6168-8599
Yoshiharu MorimotoIVF Japan Group, HORAC Grand Front Osaka Clinic, Osaka, Japan.ORCID https://orcid.org/0000-0003-2834-2726
Marco G AlvesDepartment of Anatomy and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0001-7635-783X
Aleksandra SpasicDepartment of Urology, Military Medical Academy, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-6619-865X
Uros KenicUrology VUK Center, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-8791-9161
Jonathan RamsayDepartment of Andrology, Hammersmith Hospital, London, UK.ORCID https://orcid.org/0000-0002-2403-7698
Ebenezer Oluwole AkandeDepartment of Obstetrics & Gynaecology, University College Hospital, Ibadan, Nigeria.ORCID https://orcid.org/0000-0001-6694-0415
Amina OumezianeTiziri IVF Center, Algeriers, Algeria.ORCID https://orcid.org/0000-0001-5395-0710
Dmitri DozortsevAmerican College of Embryology, Houston, TX, USA.ORCID https://orcid.org/0000-0001-8304-2780
Eric ChungDepartment of Urology, University of Queensland, Brisbane, Australia.ORCID https://orcid.org/0000-0003-3373-3668
Ernestine Gwet BellOdyssèe Clinic for Assisted Reproduction, Douala, Cameroun.ORCID https://orcid.org/0000-0001-6820-2686
Adolfo AllegraANDROS Day Surgery Clinic, Reproductive Medicine Unit, Palermo, Italy.ORCID https://orcid.org/0000-0001-9942-7810
Vasilios TanosDepartment of Obstetrics and Gynecology, University of Nicosia Medical School, Nicosia, Cyprus.ORCID https://orcid.org/0000-0002-4695-4630
Moïse FiadjoeBiasa Fertility Clinic, Lomè, Togo.ORCID https://orcid.org/0000-0002-5614-8552
Timur GurganDepartment of Obstetrics and Gynecology, Bahcesehir University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-6738-792X
Michel Abou-AbdallahMiddle East Fertility Society, Canadian Foundation for Reproductive Medicine, Lebanon.ORCID https://orcid.org/0000-0003-0955-8839
Hazem Al-RumaihReproductive Medicine Unit, New Jahra Hospital, Ministry of Health, Al Jahra, Kuwait.ORCID https://orcid.org/0000-0002-9835-5314
Ivana ObornaFertimed Ltd., Olomouc, Czech Republic.ORCID https://orcid.org/0000-0003-1978-4733
Hesham ArabRMU Dr. Arab Medical Center, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0001-8267-5906
Sandro EstevesANDROFERT, Andrology & Human Reproduction Clinic, Campinas, Brazil.ORCID https://orcid.org/0000-0002-1313-9680
Medhat AmerDepartment of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0001-9129-2333
Ates KadiogluSection of Andrology, Istanbul Faculty of Medicine, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-4239-7638
Oleksandr YuzkoDepartment of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine.ORCID https://orcid.org/0000-0003-1270-9095
Vladislav KorsakInternational Centre for Reproductive Medicine, Saint-Petersburg, Russia.ORCID https://orcid.org/0000-0001-5462-0756
Rupin ShahDepartment of Urology, Lilavati Hospital and Research Centre, Mumbai, India.ORCID https://orcid.org/0000-0002-7868-5949
American Society for Reproductive Medicine · USCairo University · EGInstitute for Human Reproduction · USRoyan Institute · IRAlexandria University · EGAndros Clinica Day Surgery · ITAnkara University · TRAustrian Competence Centre of Food Safety · ATBahçeşehir University · TRBukovinian State Medical University · UACARE Fertility · USCenter for Health, Exercise and Sport Sciences · RSChinese University of Hong Kong · HKCleveland Clinic · USCooper University Hospital · USDepartment of Embryology · USÉcole des Hautes Études Commerciales · MAÉcole Nationale Supérieure d'Informatique · DZFaculdade de Medicina do ABC · BRFertility Medical Group · BR
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe use of antioxidants is common practice in the management of infertile patients. However, there are no established guidelines by professional societies on antioxidant use for male infertility. MATERIALS AND
methodsUsing an online survey, this study aimed to evaluate the practice pattern of reproductive specialists to determine the clinical utility of oxidative stress (OS) testing and antioxidant prescriptions to treat male infertility.
resultsResponses from 1,327 participants representing 6 continents, showed the largest participant representation being from Asia (46.8%). The majority of participants were attending physicians (59.6%), with 61.3% having more than 10 years of experience in the field of male infertility. Approximately two-thirds of clinicians (65.7%) participated in this survey did not order any diagnostic tests for OS. Sperm DNA fragmentation was the most common infertility test beyond a semen analysis that was prescribed to study oxidative stress-related dysfunctions (53.4%). OS was mainly tested in the presence of lifestyle risk factors (24.6%) or sperm abnormalities (16.3%). Interestingly, antioxidants were prescribed by 85.6% of clinicians, for a duration of 3 (43.7%) or 3-6 months (38.6%). A large variety of antioxidants and dietary supplements were prescribed, and scientific evidence were mostly considered to be modest to support their clinical use. Results were not influenced by the physician's age, geographic origin, experience or training in male infertility.
conclusionsThis study is the largest online survey performed to date on this topic and demonstrates 1) a worldwide understanding of the importance of this therapeutic option, and 2) a widely prevalent use of antioxidants to treat male infertility. Finally, the necessity of evidence-based clinical practice guidelines from professional societies is highlighted.
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AntioxidantsMale infertilityOxidative stressReproduction, physiciansSurvey
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