Evidence map›Paper›PMID 33831549›Full record

ArticleFree radical biology & medicine2021

Elemental iron modifies the redox environment of the gastrointestinal tract: A novel therapeutic target and test for metabolic syndrome.

Charlene B Van Buiten, Guojun Wu, Yan Y Lam, Liping Zhao, Ilya Raskin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Dietary Polyphenols SupportAntioxidants (Basel, Switzerland) · 2024
    Article
  2. Article
  3. Jiedu-Yizhi Formula Alleviates Neuroinflammation in AD Rats by Modulating the Gut Microbiota.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Charlene B Van BuitenDepartment of Food Science and Human Nutrition, College of Health and Human Sciences, Colorado State University, Fort Collins, CO, 80525, USA; Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA. Electronic address: charlene.vanbuiten@colostate.edu.
Guojun WuDepartment of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA; Center for Microbiome, Nutrition and Health, New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, NJ, 80901, USA.
Yan Y LamDepartment of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA; Center for Microbiome, Nutrition and Health, New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, NJ, 80901, USA.
Liping ZhaoDepartment of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA; Center for Microbiome, Nutrition and Health, New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, NJ, 80901, USA.
Ilya RaskinDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, 08901, USA.
Rutgers, The State University of New Jersey · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
Training in Botanical Approaches to Combat Metabolic SyndromeT32AT004094 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BRANTLEY, PHILLIP J, STEPHENS, JACQUELINE M · 2009 to 2024
$5.7M
Health promoting effects of high-polyphenol foods may be mediated through gut microbiomeR01AT008618 · NCCIH · RUTGERS, THE STATE UNIV OF N.J. · PI RASKIN, ILYA · 2015 to 2019
$2.2M
NCCIH NIH HHS R01 AT008618NCCIH NIH HHS T32 AT004094NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

Metabolic syndrome (MetS, i.e., type 2 diabetes and obesity) is often associated with dysbiosis, inflammation, and leaky gut syndrome, which increase the content of oxygen and reactive oxygen species (ROS) in the gastrointestinal (GI) tract. Using near-infrared fluorescent, in situ imaging of ROS, we evaluated the effects of oral administration of elemental iron powder (Fe

Indexed as

Diabetes Mellitus, Type 2Metabolic SyndromeAnimalsDiet, High-FatGastrointestinal TractIronMiceMice, Inbred C57BLOxidation-ReductionIronIronLeaky gutMetabolic syndromeMicrobiomeReactive oxygen species

Identifiers

PMID33831549
PMCPMC8544024
OpenAlexW3146390578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.