Evidence map›Paper›PMID 33831360›Full record

ArticleNeuron2021

Revisiting dopamine-acetylcholine imbalance in Parkinson's disease: Glutamate co-transmission as an exciting partner in crime.

Yan-Feng Zhang, Stephanie J Cragg

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yan-Feng ZhangDepartment of Physiology, Anatomy and Genetics, and Oxford Parkinson's Disease Centre, University of Oxford, Oxford OX1 3PT, UK.
Stephanie J CraggDepartment of Physiology, Anatomy and Genetics, and Oxford Parkinson's Disease Centre, University of Oxford, Oxford OX1 3PT, UK. Electronic address: stephanie.cragg@dpag.ox.ac.uk.
University of Oxford · GB

Funding

Medical Research Council G0700932Medical Research Council MR/J004324/1Medical Research Council MR/K013866/1Medical Research Council MR/V013599/1Parkinson's UK G-0803Parkinson's UK G-0808Parkinson's UK G-1103Parkinson's UK G-1305Parkinson's UK G-1504Parkinson's UK H-1003Parkinson's UK J-0901
6 · The paper itself

Abstract

Striatal dopamine and acetylcholine are thought to be imbalanced in Parkinson's disease. In this issue of Neuron, Cai et al. report that restoration of nigral glutamate co-transmission, acting on dorsolateral striatal cholinergic interneuron mGluR1s, can rescue motor dysfunction in a mouse model of Parkinson's.

Indexed as

Motor DisordersParkinson DiseaseAcetylcholineAnimalsCholinergic AgentsCorpus StriatumCrimeDopamineGlutamic AcidInterneuronsMiceAcetylcholineCholinergic AgentsDopamineGlutamic Acid

Identifiers

PMID33831360
OpenAlexW3144770483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.