SynthesisJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2021
Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAX
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- The effects of omega-3 polyunsaturated fatty acids on muscle and whole-body protein synthesis: a systematic review and meta-analysis.Nutrition reviews · 2025Pooled it
- Recent sarcopenia definitions-prevalence, agreement and mortality associations among men: Findings from population-based cohorts.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Comparing Prevalence of Sarcopenia Using Twelve Sarcopenia Definitions in a Large Multinational European Population of Community-Dwelling Older Adults.The journal of nutrition, health & aging · 2023Trial
- Objective Physical Performance Predicts 10-Year Fracture Risk Without Densitometry in Older Men and Women: Development and Head-to-Head Comparison with FRAX in MrOS and SOF.Calcified tissue international · 2026Article
- Links between bone fractures and the gut microbiota.Nature reviews. Endocrinology · 2026Review
- Associations of muscle strength and functional power with longitudinal change in HR-pQCT bone parameters: the Osteoporotic Fractures in Men (MrOS) Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- The Osteoporotic Fractures in Men study (MrOS): a 25-yr landmark study of skeletal health in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38 123 UK Biobank participants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Sarcopenia and fall-related outcomes in Chinese adults aged 45 years or older: a longitudinal cohort study.Scientific reports · 2026Article
- Grip strength but not stair climb power is associated with injurious falls in middle-aged and older women: The Study of Women's Health Across the Nation (SWAN).Archives of osteoporosis · 2026Article
- Corticosteroid, Parathyroid Hormone, and Body Composition Associations With Bone Density and Structure Following Kidney Transplantation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Longitudinal trajectories of walking speed and risk of incident hip fracture in osteoporosis: a group-based trajectory modeling analysis from HRS, ELSA and SHARE.Frontiers in public health · 2026Article
- Adverse outcomes of sarcopenic obesity in older adults: a scoping review.Frontiers in nutrition · 2026Review
- Is trabecular bone score associated with appendicular lean mass?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Are low-trauma fractures all fragility fractures? Insights into musculoskeletal and body composition characteristics of community-dwelling post-menopausal women with a recent fracture.Aging clinical and experimental research · 2025Article
- Recent Sarcopenia Definitions-Variability in Prevalence and Disability Associations in Peritoneal Dialysis Patients.Journal of cachexia, sarcopenia and muscle · 2025Article
- Sarcopenia is associated with increased hip fracture risk among middle-aged and elderly Chinese adults in longitudinal analysis of CHARLS data.Scientific reports · 2025Article
- Prediction of 10-Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort.Journal of cachexia, sarcopenia and muscle · 2025Article
- Association of a Combined Body Mass Index and Regional Body Fat Percentage Metric With Fragility Fracture Risk: Evidence from a Large Observational Cohort.Journal of cachexia, sarcopenia and muscle · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 14 institutions in 7 countries.
Nicholas C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.ORCID 0000-0002-8194-2512
Eric OrwollOregon Health & Science University, Portland, OR, USA.
Timothy KwokDepartment of Medicine and Therapeutics and School of Public Health, The Chinese University of Hong Kong, Shatin, Hong Kong.
Magnus K KarlssonClinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmo, Lund University and Department of Orthopedics, Skane University Hospital, Malmo, Sweden.
Björn E RosengrenClinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmo, Lund University and Department of Orthopedics, Skane University Hospital, Malmo, Sweden.
Eva RibomDepartment of Surgical Sciences, University of Uppsala, Uppsala, Sweden.
Jane A CauleyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-0752-4408
Peggy M CawthonResearch Institute, California Pacific Medical Center, San Francisco, CA, USA.ORCID 0000-0003-4938-9478
Kristine EnsrudMedicine and Epidemiology & Community Health, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-9069-3036
Enwu LiuMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Alfonso J Cruz-JentoftServicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.
Roger A FieldingNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Cyrus CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.ORCID 0000-0003-3510-0709
John A KanisMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Mattias LorentzonMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.ORCID 0000-0003-0749-1431
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Center for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Dan MellströmDepartment of Internal Medicine and Clinical Nutrition, Center for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Helena JohanssonMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Eugene McCloskeyCentre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
Alberta Bone and Joint Health Institute · CAAustralian Catholic University · AULund University · SESahlgrenska University Hospital · SEUniversity Hospital Southampton NHS Foundation Trust · GBChinese University of Hong Kong · HKInstituto Ramón y Cajal de Investigación Sanitaria · ESOregon Health & Science University · USTufts University · USUniversity of California, San Francisco · USUniversity of Gothenburg · SEUniversity of Minnesota · USUniversity of Pittsburgh · USUppsala University · SE
Funding
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4MOregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7MLong term fracture risk and change in peripheral bone in the oldest old men: The MrOS studyR01AG066671 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI BOUXSEIN, MARY L, CAWTHON, PEGGY MANNEN · 2020 to 2024
$13.3MOsteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3MOsteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3MOsteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1MOsteoporotic Fractures in Men (MrOS) - PortlandU01AG042124 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2013 to 2019
$3.0MOsteoporatic Fractures in Men (MrOS)U01AG042168 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KADO, DEBORAH · 2013 to 2017
$3.0MOsteoporotic Fractures in Men (Mr. Os) Palo AltoU01AG042143 · NIA · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L. · 2013 to 2017
$3.0MOsteoporotic Fractures in Men (Mr.OS)U01AG042139 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2013 to 2017
$2.9MOsteoporotic Fractures in Men_MrOS Renewal_BirminghamU01AG042140 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHIKANY, JAMES M · 2013 to 2019
$2.7MLong-term fracture risk in older men: the MrOS studyR56AG061085 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI BOUXSEIN, MARY L, CAWTHON, PEGGY MANNEN · 2019 to 2019
$1.3MMedical Research Council 4050502589Medical Research Council G0400491Medical Research Council MC_PC_21000Medical Research Council MC_PC_21001Medical Research Council MC_PC_21003Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR002369NIAMS NIH HHS U01 AR066160NIA NIH HHS R01 AG066671NIA NIH HHS R56 AG061085NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168Versus Arthritis 17702
Abstract
Dual-energy X-ray absorptiometry (DXA)-derived appendicular lean mass/height
Indexed as
Osteoporotic FracturesSarcopeniaAbsorptiometry, PhotonAccidental FallsAgedBone DensityHumansMaleRisk AssessmentRisk FactorsEPIDEMIOLOGYFALLSFRACTUREFRAXINTERACTIONOSTEOPOROSISSARCOPENIA
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.