Trial reportInteractive cardiovascular and thoracic surgery2021
Comparison of early postoperative cytokine changes in patients undergoing intubated and non-intubated thoracic surgery: a randomized controlled trial.
Trial report in Interactive cardiovascular and thoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04007354 (Comparison of the Inflammatory Response After One-lung Ventilation With Positive Ventilation and Self-respiration), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Inflammatory Response After One-lung Ventilation With Positive Ventilation and Self-respiration
Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Tubeless anesthesia improves postoperative recovery following VATS wedge resection: a prospective randomized controlled study.BMC surgery · 2025Trial
- Review
- Short-term and long-term outcomes of non-tracheal intubation anesthesia in thoracoscopic lobectomy for lung cancer: A systematic review and meta-analysis.Molecular and clinical oncology · 2026Article
- Comparison of short-term outcomes between non-intubated and intubated video-assisted thoracoscopic surgery: a propensity score matching analysis.Journal of thoracic disease · 2025Article
- Emergency thoracoscopic exploration under nonintubated general anesthesia preserved spontaneous ventilation after bilateral lung transplantation: a rare case report.BMC anesthesiology · 2025Article
- Risk of short-term cardiovascular disease in relation to the mode of delivery in singleton pregnancies: a retrospective cohort study.EClinicalMedicine · 2024Article
- Nonintubated versus Intubated Lung Volume Reduction Surgery in Patients with End-Stage Lung Emphysema and Hypercapnia.Journal of clinical medicine · 2023Article
- Thoracic surgery in the non-intubated spontaneously breathing patient.Respiratory research · 2022Review
- Feasibility of Nonintubated Anesthesia for Lumboperitoneal Shunt Implantation.Clinics and practice · 2022Article
- Non-intubated video-assisted thoracoscopic surgery under combination of erector spinae plane block and thoracic paravertebral block.BMC anesthesiology · 2022Article
- Pathophysiological Advantages of Spontaneous Ventilation.Frontiers in surgery · 2022Review
- Perioperative Inflammatory Response and Cancer Recurrence in Lung Cancer Surgery: A Narrative Review.Frontiers in surgery · 2022Review
- Perioperative Systemic Inflammation in Lung Cancer Surgery.Frontiers in surgery · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe inflammatory response after surgery is associated with patient prognosis. Patients who undergo thoracic surgery exhibit a profound systemic inflammatory response due to the surgical procedures used and application of one-lung ventilation. The aim of this study was to compare perioperative inflammatory changes in patients after intubated and non-intubated thoracic surgery for primary lung cancer resection.
methodsThis prospective randomized controlled study included forty patients who underwent surgical resection for stage I non-small-cell lung cancer. Blood samples for cytokine analysis were collected just before induction, at 1 and 24 h after surgery. Levels of the pro-inflammatory cytokine and anti-inflammatory cytokines were measured using quantitative sandwich enzyme immunoassay kits.
resultsThe basal values of cytokines were comparable between 2 groups. Within each group, the postoperative levels of interleukin (IL)-1, IL-6 and tumour necrosis factor-α increased, while those of IL-4 and IL-10 did not change significantly. The levels of IL-6 and tumour necrosis factor-α were significantly lower in group NI at 1 and 24 h postoperatively. Other cytokines did not differ in both groups during postoperative period. The IL-6/IL-10 ratio at 1 h after surgery was lower in non-intubated patients than in intubated patients, but there was no difference at 24 h after surgery.
conclusionsNon-intubated thoracic surgery may attenuate the early inflammatory cytokine changes following major resection for primary lung cancer compared with intubated conventional surgery. CLINICAL
trial registrationClinicalTrials.gov registry number NCT04007354.
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