ArticleAmerican journal of epidemiology2021
Mid- to Late-Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study.
Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk, protective, and biomarkers of dementia in Indigenous peoples: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Late-life body mass index and amyloid interaction on cognitive decline in unimpaired older adults.The journal of prevention of Alzheimer's disease · 2026Trial
- A randomized controlled trial on the effects of traditional Thai mind-body exercise (Ruesi Dadton) on biomarkers in mild cognitive impairment.European journal of physical and rehabilitation medicine · 2024Trial
- Exercise attenuates obesity-related cognitive and sleep-circadian dysfunctions by attenuating neuroinflammation via JAK/STAT in sex and age specific manner.International journal of obesity (2005) · 2026Article
- GLP-1 receptor agonists, metabolic syndrome, and Alzheimer's disease: Lessons and opportunities from the EVOKE trials.Journal of neuroendocrinology · 2026Review
- Cohort profile: a community-based prospective cohort study of Alzheimer's disease and related dementias in the Democratic Republic of Congo.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Sex differences in modifiable risk factors of dementia and their associations with cognition.Biology of sex differences · 2026Article
- Mapping the network structure of dementia and its associated factors among older adults in Singapore: evidence from two national cross-sectional studies.BMC geriatrics · 2026Article
- Association of metabolic obesity phenotypes with cognitive decline in the ELSA-Brasil study.Diabetes, obesity & metabolism · 2026Article
- Association of midlife macronutrient and mineral intake with subjective cognitive complaints in a prospective cohort of women.European journal of nutrition · 2026Article
- A multilevel conceptual framework for dementia: from life-course mechanisms to public health strategies.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Review
- Increased risk of incident dementia associated with vitamin D deficiency in glaucoma patients: a TriNetX cohort study.Frontiers in nutrition · 2026Article
- Relationship Between Apolipoprotein E Genotypes, Unhealthy Weight Status, and Cognitive Impairment in Older Adults of Predominantly African Descent.Diseases (Basel, Switzerland) · 2025Article
- Association of adiposity evaluated by anthropometric and bioelectrical impedance analysis measures with cognitive performance in the ELSA-Brasil study.International journal of obesity (2005) · 2025Article
- High-fat feeding has sex-dependent effects on the structure and biomechanical properties of cerebral parenchymal arterioles and cognitive function.American journal of physiology. Heart and circulatory physiology · 2025Article
- Heterogeneous treatment effects of GLP-1RAs and SGLT2is on risk of Alzheimer's disease and related dementia in patients with type 2 diabetes: Insights from a real-world target trial emulation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association of Body Mass Index in Late Life, and Change from Midlife to Late Life, With Incident Dementia in the ARIC Study Participants.Neurology · 2025Observational
- Metabolic dysfunction-associated steatotic liver disease, metabolic alcohol-related liver disease, and incident dementia: a nationwide cohort study : MASLD, MetALD, and dementia risk.BMC gastroenterology · 2025Article
- Greater BMI across the lifespan is associated with better midlife cognition: The Bogalusa Heart Study.Scientific reports · 2025Article
- Associations of Mid- and Late-Life Fasting Blood Glucose Levels With Dementia Risk Among Patients With Diabetes: Framingham Heart Study.European journal of neurology · 2025Article
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Abstract
Growing evidence relates body mass index (BMI) to poorer health outcomes; however, results across studies associating BMI and dementia are conflicting. A total of 3,632 Framingham Offspring participants aged 20 to 60 years at their second health examination (1979-1983) were included in this study, with 190 cases of incident dementia identified by 2017. Cox proportional hazards regression models were fitted to investigate the association of BMI at each of their 8 exams as a baseline for dementia risk and the associations between obesity and dementia across age groups. Spline models were fitted to investigate nonlinear associations between BMI and dementia. Each 1-unit increase in BMI at ages 40-49 years was associated with higher risk of dementia, but with lower risk after age 70 years. Obesity at ages 40-49 years was associated with higher risk of dementia. Overall, the relationship between BMI and dementia risk was heterogeneous across the adult age range. Monitoring BMI at different ages might mediate risk for dementia across an individual's lifetime.
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