Evidence map›Paper›PMID 33831177›Full record

Observational studyAmerican journal of epidemiology2021

Snowball Sampling Study Design for Serosurveys Early in Disease Outbreaks.

Lee Kennedy-Shaffer, Xueting Qiu, William P Hanage

Abstract readObservational Study
In one paragraph

Observational study in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Diagnostic odyssey and healthcare access challenges in Rett Syndrome: perspectives from Brazilian families.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026
    Article
  4. Article
  5. Article
  6. Social Influence in Australian University Institutional Eating: A Qualitative Content Analysis.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2025
    Article
  7. Article
  8. Article
  9. Nurse-led social entrepreneurship as a career.Health SA = SA Gesondheid · 2025
    Article
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  11. Article
  12. Observational
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lee Kennedy-Shaffer
Xueting Qiu
William P Hanage

Funding

Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI LIPSITCH, MARC · 2009 to 2018
$26.4M
NCIRD CDC HHS U01 IP001121NIGMS NIH HHS U54 GM088558
6 · The paper itself

Abstract

Serological surveys can provide evidence of cases that were not previously detected, depict the spectrum of disease severity, and estimate the proportion of asymptomatic infections. To capture these parameters, survey sample sizes may need to be very large, especially when the overall infection rate is still low. Therefore, we propose the use of "snowball sampling" to enrich serological surveys by testing contacts of infected persons identified in the early stages of an outbreak. For future emerging pandemics, this observational study sampling design can answer many key questions, such as estimation of the asymptomatic proportion of all infected cases, the probability of a given clinical presentation for a seropositive individual, or the association between characteristics of either the host or the infection and seropositivity among contacts of index individuals. We provide examples, in the context of the coronavirus disease 2019 (COVID-19) pandemic, of studies and analysis methods that use a snowball sample and perform a simulation study that demonstrates scenarios where snowball sampling can answer these questions more efficiently than other sampling schemes. We hope such study designs can be applied to provide valuable information to slow the present pandemic as it enters its next stage and in early stages of future pandemics.

Indexed as

Computer SimulationContact TracingCOVID-19HumansPandemicsSampling StudiesSARS-CoV-2Seroepidemiologic Studiesasymptomatic infectioncontact tracingcoronavirus disease 2019design effectSARS-CoV-2serosurvey samplingtransmission chain

Identifiers

PMID33831177
PMCPMC8083564

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.