Evidence map›Paper›PMID 33831096›Full record

ArticlePloS one2021

Sex-differences in circulating biomarkers during acute myocardial infarction: An analysis from the SWEDEHEART registry.

Kai M Eggers, Lars Lindhagen, Tomasz Baron, David Erlinge, Marcus Hjort, Tomas Jernberg, Nina Johnston, György Marko-Varga, Melinda Rezeli, Jonas Spaak and 1 more

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In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kai M EggersDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8806-5778
Lars LindhagenDepartment of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Tomasz BaronDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
David ErlingeDepartment of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.
Marcus HjortDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Tomas JernbergDivision of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.
Nina JohnstonDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
György Marko-VargaDepartment of Biomedical, Clinical Protein Science & Imaging, Engineering, Lund University, Lund, Sweden.
Melinda RezeliDepartment of Biomedical, Clinical Protein Science & Imaging, Engineering, Lund University, Lund, Sweden.
Jonas SpaakDivision of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-2135-1294
Bertil LindahlDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex-differences in the pathobiology of myocardial infarction are well established but incompletely understood. Improved knowledge on this topic may help clinicians to improve management of men and women with myocardial infarction.

methodsIn this registry-based cohort study (SWEDEHEART), we analyzed 175 circulating biomarkers reflecting various pathobiological axes in 856 men and 243 women admitted to Swedish coronary care units because of myocardial infarction. Two multimarker panels were applied (Proximity Extension Assay [Olink Bioscience], Multiple Reaction Monitoring mass spectrometry). Lasso analysis (penalized logistic regression), multiple testing-corrected Mann-Whitney tests and Cox regressions were used to assess sex-differences in the concentrations of these biomarkers and their implications on all-cause mortality and major adverse events (median follow-up up to 6.6 years).

resultsBiomarkers provided a very high discrimination between both sexes, when considered simultaneously (c-statistics 0.972). Compared to women, men had higher concentrations of six biomarkers with the most pronounced differences seen for those reflecting atherogenesis, myocardial necrosis and metabolism. Women had higher concentrations of 14 biomarkers with the most pronounced differences seen for those reflecting activation of the renin-angiotensin-aldosterone axis, inflammation and for adipokines. There were no major variations between sexes in the associations of these biomarkers with outcome.

conclusionsSeverable sex-differences exist in the expression of biomarkers in patients with myocardial infarction. While these differences had no impact on outcome, our data suggest the presence of various sex-related pathways involved in the development of coronary atherosclerosis, the progression to plaque rupture and acute myocardial damage, with a greater heterogeneity in women.

Indexed as

AgedBiomarkersFemaleHumansMaleMiddle AgedMyocardial InfarctionSex FactorsBiomarkers

Identifiers

PMID33831096
PMCPMC8031406

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.