ArticlePloS one2021
Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis.BMC geriatrics · 2023Pooled it
- Diabetes Distress in Adults with Type 2 Diabetes and Multimorbidity: A Scoping Review.Journal of multidisciplinary healthcare · 2026Review
- Artificial intelligence-driven risk prediction of polypharmacy in older adults: current advances, clinical applications, and future perspectives.Frontiers in public health · 2026Review
- Polypharmacy following Dementia Diagnoses in Vietnam: Results from Real-World Data in Outpatient Settings.Gerontology · 2026Article
- Polypharmacy and associated factors among patients with type two diabetes mellitus with comorbidity: a multicenter cross-sectional study in Northwest Ethiopia.BMC endocrine disorders · 2025Article
- Vildagliptin promotes diabetic foot ulcer healing through autophagy modulation.Diabetology & metabolic syndrome · 2024Article
- Comorbidities and use of health services in people with diabetes mellitus according to risk levels by adjusted morbidity groups.BMC endocrine disorders · 2024Article
- Review
- Everyday disease diplomacy: an ethnographic study of diabetes self-care in Vietnam.BMC public health · 2022Article
- Potential for Prebiotic StabilizedAntioxidants (Basel, Switzerland) · 2022Article
- Barriers and facilitators of medication adherence in the management of Diabetes among the Brazilian Amazon population.Revista CuidarteArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPeople with diabetes are at high risk of polypharmacy owing to complex treatment of diabetes and comorbidities. Polypharmacy is associated with increased risk of adverse reactions and decreased compliance. Therefore, the objectives of this study were to assess polypharmacy in people with type 2 diabetes (T2D) and associated diabetes-related factors in rural areas in Vietnam.
methodPeople with T2D (n = 806) who had received treatment for diabetes at a district hospital were invited to participate in a questionnaire-based cross-sectional survey. Polypharmacy was defined as ≥5 types of medicine and assessed as a) prescription medicine and non-prescription/over the counter (OTC) medicine and b) prescription medicine and non-prescription/OTC, herbal and traditional medicine, and dietary supplement. Multiple logistic regression was used to investigate the association between polypharmacy and diabetes specific factors: duration, comorbidities and diabetes-related distress.
resultsOf the people with T2D, 7.8% had a medicine use corresponding to polypharmacy (prescription medicine and non-prescription/OTC), and 40.8% when herbal and traditional medicine, and dietary supplement were included. Mean number of medicine intake (all types of medicines and supplements) were 3.8±1.5. The odd ratios (ORs) of polypharmacy (medicine and supplements) increased with diabetes duration (<1-5 years OR = 1.66; 95%CI: 1.09-2.53 and >5 years OR = 1.74; 95%CI: 1.14-2.64 as compared to ≤1-year duration of diabetes), number of comorbidities (1-2 comorbidities: OR = 2.0; 95%CI: 1.18-3.42; ≥3 comorbidities: OR = 2.63;95%CI: 1.50-4.61 as compared to no comorbidities), and suffering from diabetes-related distress (OR = 1.49; 95%CI: 1.11-2.01) as compared to those without distress.
conclusionsIn rural northern Vietnam, persons with longer duration of T2D, higher number of comorbidities and diabetes-related stress have higher odds of having a medicine use corresponding to polypharmacy. A high proportion of people with T2D supplement their prescription, non-prescription/OTC medicine with herbal and traditional medicine and dietary supplements.
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